Günthard
Fakultäten » Medizinische Fakultät » Infektionskrankheiten und Spitalhygiene, Klinik für » Prof. Dr. Huldrych Günthard » Günthard
Completed research project
| Title / Titel | Completing the Swiss HIV-Cohort drug resistance database: A comprehensive, longitudinal, representative tool to address resistance at at the level of basic, epidemiological and clinical science. | ||||||
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| Abstract (PDF, 14 KB) | |||||||
| Summary / Zusammenfassung | The overall goal of this proposal is to complement the already successfully running SHCS-drug resistance database by extensive retrospective genotyping. Availability of a baseline sequence before patients will undergo antiretroviral therapy will form the base of a variety of highly important research projects: a) Anonymous molecular epidemiological studies will allow to draw a picture of the Swiss epidemic of unreached quality. This data for the first time will allow to reconstruct the epidemic in a sample size representative of a whole country. b) The quality of treatment related drug resistance studies will substantially gain in quality because baseline sequences are a prerequisite to prove that drug resistance actually has emerged due to a certain treatment failing regimen and was not already present at baseline due to transmitted drug resistance. c) An exact picture of transmitted drug resistance on the population level will be possible longitudinally. d) The wealth of sequence data and anonymous linkage by phylogenetic analysis will allow to identify transmission pairs. Such identification of transmission pairs will allow in depth biological studies (also based on the plasma and cell repository of the SHCS) to further characterize biological characteristics of virus and host explaining transmission events. e) Correlation of viral sequence data and clinical course of SHCS patients on a large scale will help to identify viral and host virulence markers on the population level. f) The large amount of baseline sequence data will allow us to identify viral mutational patterns predicting response respectively failure of certain drug regimens. g) Identification of viral subtypes and correlation of treatment responses and clinical outcome will shed light on the fact whether viral subtypes show different responses to antiretroviral treatment. Taken together, we will obtain an HIV-1 nucleotide sequence database that linked to the wealth of clinical data of the SHCS will be of unique quality. | ||||||
| Publications / Publikationen | Von Wyl V, Yerly S, Böni J, Bürgisser P, Klimkait T, Battegay M, Furrer H, Telenti A, Hirschel B, Vernazza P, Bernasconi E, Rickenbach M, Perrin L, Ledergerber B, Günthard HF, for the SHCS. Emergence of HIV-1 drug resistance in previously untreated patients initiating combination antiretroviral treatment: A comparison of different regimen types. Archives of Internal Medicine 2007;167:1782-1790.Yerly, S, von Wyl V, Böni J, Schüpbach J, Burgisser P, Klimkait T, Rickenbach M, Ledergerber B, Kaiser L, Günthard HF, Perrin L, and the Swiss HIV Cohort Study. Transmission of HIV-1 drug resistance in Switzerland: A 10 year molecular epidemiology survey. AIDS. 2007;21:2223-2229Weitere Informationen | ||||||
| Keywords / Suchbegriffe | HIV drug resistance, database, antiretroviral treatment, Swiss HIV Cohort Study, | ||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Foundation, Private Sector (e.g. Industry) Swiss HIV Cohort Study, UBS-Foundation |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Jun 2007 to May 2010 |