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Günthard

Fakultäten » Medizinische Fakultät » Infektionskrankheiten und Spitalhygiene, Klinik für » Prof. Dr. Huldrych Günthard » Günthard

Completed research project

Title / Titel Completing the Swiss HIV-Cohort drug resistance database: A comprehensive, longitudinal, representative tool to address resistance at at the level of basic, epidemiological and clinical science.
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung The overall goal of this proposal is to complement the already successfully running SHCS-drug resistance database by extensive retrospective genotyping. Availability of a baseline sequence before patients will undergo antiretroviral therapy will form the base of a variety of highly important research projects: a) Anonymous molecular epidemiological studies will allow to draw a picture of the Swiss epidemic of unreached quality. This data for the first time will allow to reconstruct the epidemic in a sample size representative of a whole country. b) The quality of treatment related drug resistance studies will substantially gain in quality because baseline sequences are a prerequisite to prove that drug resistance actually has emerged due to a certain treatment failing regimen and was not already present at baseline due to transmitted drug resistance. c) An exact picture of transmitted drug resistance on the population level will be possible longitudinally. d) The wealth of sequence data and anonymous linkage by phylogenetic analysis will allow to identify transmission pairs. Such identification of transmission pairs will allow in depth biological studies (also based on the plasma and cell repository of the SHCS) to further characterize biological characteristics of virus and host explaining transmission events. e) Correlation of viral sequence data and clinical course of SHCS patients on a large scale will help to identify viral and host virulence markers on the population level. f) The large amount of baseline sequence data will allow us to identify viral mutational patterns predicting response respectively failure of certain drug regimens. g) Identification of viral subtypes and correlation of treatment responses and clinical outcome will shed light on the fact whether viral subtypes show different responses to antiretroviral treatment. Taken together, we will obtain an HIV-1 nucleotide sequence database that linked to the wealth of clinical data of the SHCS will be of unique quality.
Publications / Publikationen Von Wyl V, Yerly S, Böni J, Bürgisser P, Klimkait T, Battegay M, Furrer H, Telenti A, Hirschel B, Vernazza P, Bernasconi E, Rickenbach M, Perrin L, Ledergerber B, Günthard HF, for the SHCS. Emergence of HIV-1 drug resistance in previously untreated patients initiating combination antiretroviral treatment: A comparison of different regimen types. Archives of Internal Medicine 2007;167:1782-1790.

Yerly, S, von Wyl V, Böni J, Schüpbach J, Burgisser P, Klimkait T, Rickenbach M, Ledergerber B, Kaiser L, Günthard HF, Perrin L, and the Swiss HIV Cohort Study. Transmission of HIV-1 drug resistance in Switzerland: A 10 year molecular epidemiology survey. AIDS. 2007;21:2223-2229

Weitere Informationen

Keywords / Suchbegriffe HIV drug resistance, database, antiretroviral treatment, Swiss HIV Cohort Study,
Project leadership and contacts /
Projektleitung und Kontakte
Prof.§ Huldrych Günthard, MD (Project Leader) huldrych.guenthard@usz.ch
Funding source(s) /
Unterstützt durch
Foundation, Private Sector (e.g. Industry)
Swiss HIV Cohort Study, UBS-Foundation
In collaboration with /
In Zusammenarbeit mit
Viktor von Wyl, Bruno Ledergerber, Division of Infectious Diseases, University Hospital Zurich, Zurich
Jürg Böni, Swiss National Center for Retroviruses, University Hospital Zurich, Zurich
Switzerland
Sebastian Bonhoeffer, Institute of Integrative Biology, Federal Institute of Technology, Zurich Switzerland
Philip Bürgisser, Laboratory of Clinical Immunology, CHUV, Lausanne
Sabine Yerly, Laboratory of Clinical Virology, HCUG, Geneva
Martin Rickenbach, Data Center of the Swiss HIV Cohort Study, CHUV, Lausanne
Switzerland
Duration of Project / Projektdauer Jun 2007 to May 2010