Baumgartner
Fakultäten » Medizinische Fakultät » Neurologie, Klinik für » Prof. Dr. Ralf Werner Baumgartner » Baumgartner
Completed research project
| Title / Titel | Role of Wall Stress in the Pathogenesis of Spontaneous Dissection of the Cervical Carotid Artery. | ||||||||
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| Abstract (PDF, 14 KB) | |||||||||
| Summary / Zusammenfassung | Spontaneous dissection of the cervical internal carotid artery (sICAD) is a major cause of stroke in young adults. The etiology of sICAD is an intimal tear of the cervical internal carotid artery (ICA) leading to intramural hemorrhage. The mechanism causing the intimal lesion is still unclear. The working hypothesis is that sICAD is due to an increased wall stress induced by minor traumas. The aim of the planned study is to compare the wall stress in the cervical ICA during static and dynamic positions of the head in patients with sICAD and healthy volunteers. In the first part of the planned study, magnetic resonance imaging (MRI) protocols will be improved to define the static and dynamic boundaries of the cervical ICA. These data will serve as an input for finite element (FE) simulations, which are performed using sophisticated computational tools. In the second part of the study, the new MRI protocols will be used for comparing patients with sICAD that occured at least 12 months ago and 15 matched healthy controls. It will be investigated whether the site of peak wall stress in the non-dissected cervical ICA occurring during static and dynamic changes of the position of the head (1) is identical in patients with sICAD and control subjects and (2) corresponds to the location of the intimal tear identified at autopsy and endarterectomy studies, and (3) the change of wall stress occurring during simulated blood pressure increase will be compared between both groups. If the planned study could show that the present working hypothesis is true, an important step in the understanding of the mechanis of so-called "spontaneous" ICAD would have been done. Thus, strategies to avoid provocative situations might be developed to prevent the occurrence and recurrence of slCAD, and improve patient management in the acute phase. | ||||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
SNF (Personen- und Projektförderung) |
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| Duration of Project / Projektdauer | May 2006 to Apr 2009 |