Schaffner
Fakultäten » Medizinische Fakultät » Klinik und Poliklinik für Innere Medizin » Prof. Dr. Andreas Schaffner (emeritiert) » Schaffner
Completed research project
| Title / Titel | Effects of activating and deactivating signals on human mononuclear phagocytes. | ||||||
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| Abstract (PDF, 14 KB) | |||||||
| Summary / Zusammenfassung | Objectives of these studies are to describe functional and biochemical changes occurring in human mononuclear phagocytes upon deactivating (such as IL-4, IL-10, Il-13 or dexamethasone) or a combination of activating and deactivating signals. Several markers of deactivation have been recognized and are studied in vitro and ex vivo in patients. The establishment of such a panel of deactivation parameters that work in human monocytes are apt to provide clinicians in the future with a monitoring system of immunosuppression such as that used in transplant patients. Currently systems for a FACS analysis for protein markers and real time PCR for m-RNA markers are under developpment and clinical study. A continuous array of new markers is contributed by a group of co-workers studying macrophage deactivation by differential display. Weitere Informationen |
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| Publications / Publikationen | Killing of Aspergillus spores depends on the anatomical source of the macrophage. Schaffner-A; Douglas-H; Braude-AI; Davis-CE. Infect-Immun. 1983 Dec; 42(3): 1109-15 Endotoxin suppresses the generation of O2- and H2O2 by "resting" and lymphokine-activated human blood-derived macrophages. Rellstab-P; Schaffner-A. J-Immunol. 1989 Apr 15; 142(8): 2813-20 Gamma-interferon restores listericidal activity and concurrently enhances release of reactive oxygen metabolites in dexamethasone-treated human monocytes. Schaffner-A; Rellstab-P. J-Clin-Invest. 1988 Sep; 82(3): 913-9 Glucocorticoid-induced impairment of macrophage antimicrobial activity: mechanisms and dependence on the state of activation. Schaffner-A; Schaffner-T. Rev-Infect-Dis. 1987 Sep-Oct; 9 Suppl 5: S620-9 In vitro susceptibility of fungi to killing by neutrophil granulocytes discriminates between primary pathogenicity and opportunism. Schaffner-A; Davis-CE; Schaffner-T; Markert-M; Douglas-H; Braude-AI. J-Clin-Invest. 1986 Aug; 78(2): 511-24. Therapeutic concentrations of glucocorticoids suppress the antimicrobial activity of human macrophages without impairing their responsiveness to gamma interferon. Schaffner-A. J-Clin-Invest. 1985 Nov; 76(5): 1755-64 Nitric oxide and infection: another view. Schoedon-G; Schneemann-M; Walter-R; Blau-N; Hofer-S; Schaffner-A Clin-Infect-Dis. 1995 Oct; 21 Suppl 2: S152-7 Modulation of the antilisterial activity of human blood-derived macrophages by activating and deactivating cytokines. Blauer-F; Groscurth-P; Schneemann-M; Schoedon-G; Schaffner-A. J-Interferon-Cytokine-Res. 1995 Feb; 15(2): 105-14 Macrophage-Aspergillus interactions. Schaffner-A Immunol-Ser. 1994; 60: 545-52 Nitric oxide synthase is not a constituent of the antimicrobial armature of human mononuclear phagocytes [see comments] Schneemann-M; Schoedon-G; Hofer-S; Blau-N; Guerrero-L; Schaffner-A. J-Infect-Dis. 1993 Jun; 167(6): 1358-63 Regulation of the L-arginine-dependent and tetrahydrobiopterin-dependent biosynthesis of nitric oxide in murine macrophages. Schoedon-G; Schneemann-M; Hofer-S; Guerrero-L; Blau-N; Schaffner-A. Eur-J-Biochem. 1993 Apr 15; 213(2): 833-9 Nitrite generation in interleukin-4-treated human macrophage cultures does not involve the nitric oxide synthase pathway. Schneemann-M; Schoedon-G; Linscheid-P; Walter-R; Blau-N; Schaffner-A. J-Infect-Dis. 1997 Jan; 175(1): 130-5 Comparison of the antimicrobial activity of deactivated human macrophages challenged with Aspergillus fumigatus and Listeria monocytogenes. Meier-Osusky-I; Schoedon-G; Blauer-F; Schneemann-M; Schaffner-A. J-Infect-Dis. 1996 Sep; 174(3): 651-4 |
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| Keywords / Suchbegriffe | macrophage, deactivation, antimicrobial activity, immunosuppression, glucocoerticoids, Il-4, Il-10, transplant infection | ||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
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| Duration of Project / Projektdauer | Oct 1983 to Oct 2006 |