Mueller Steiger

Fakultäten » Medizinische Fakultät » Infektionskrankheiten und Spitalhygiene, Klinik für » Prof. Dr. Rainer Weber » Mueller Steiger

Current research project

Title / Titel Swiss Transplant Cohort Study (STCS)
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung Transplantation is the paradigm of modern medicine. The basis of success in each individual patient lies in an interdisciplinary effort of a dedicated team, where each member is at the scientific forefront in its own field. The idea of clinical transplantation has stimulated enormous research efforts and resulted in great discoveries, which have been crucial in the transformation of clinical transplantation from an experimental to a routine procedure. Undoubtedly, beyond transplantation, many fields in medicine and patients have benefited from the cutting edge science and knowledge accumulated in the field of transplantation. Experimental transplantation such as xenotransplantation or the targeted modulation of the immune system remain a driving force behind many research activities, which have the potential to transform the field in the future. However, despite the impressive successes of the last 50 years, many questions remain. Longterm graft and patient survival is still suboptimal. Graft function and survival is related to the quality of the graft and the ability to control inflammation and rejection. Patient survival is affected by the pharmacological immune suppression and its resulting complications, such as infections and malignancies. The genetic basis for individual differences in outcome is not known. Costs play an ever increasing role, notably due to the use of newer and expensive therapies. Adherence of the individual patient to his immunosuppressive regimen is central for long-term success. Due to the relatively limited number of transplantations performed in each Swiss transplant center alone, many of these pressing issues cannot be studied in a scientifically satisfactory manner.
We propose to establish a comprehensive cohort of all transplanted individuals (pediatric and adults) in Switzerland. Data as well as specimens for each individual patient will be prospectively collected according to a defined plan. The first year will be mainly dedicated to the establishment of the core infrastructure. This cohort will provide precise and reliable data on graft, patient and donor survival. The frame of this cohort will allow prospective and retrospective studies related to the main research topics. The breadth of the different areas covered by the topics presented in the current grant proposal reflects the complexity of patient care and questions in the field of transplantation. In a unique, new, interfacultary, multicentric and interdisciplinary effort, all Swiss transplant centers have agreed to support this proposal, which will create the first nation-wide transplantation cohort in which all types of transplanted organs, solid organs and hematopoietic stem cell transplants, are included. Building on the
experience of smaller organ-specific cohorts or registries in Switzerland, this cohort initiative will enable internationally-competitive research activities. The main goal of all proposed studies is to gain new insights which will eventually result in an improved graft and patient survival and quality of life.
Keywords / Suchbegriffe cohort study; transplantation; clinical research
Project leadership and contacts /
Projektleitung und Kontakte
Prof Nicolas Mueller, MD (Project Leader)
Prof Jürg Steiger, MD (Project Leader)  
Funding source(s) /
Unterstützt durch
SNF (Personen- und Projektförderung)
In collaboration with /
In Zusammenarbeit mit
Collaboration of all centers performing transplants in Switzerland Switzerland
Duration of Project / Projektdauer Jan 2007 to Dec 2030