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Current research project

Title / Titel Genomics of vascular disease
PDF Abstract (PDF, 14 KB)
Original title / Originaltitel Genomische Untersuchungen zur Pathogenese von Gefässerkrankungen
Summary / Zusammenfassung This project investigates gene expression in different vascular beds of murine models of disease utilizing high-density cDNA microarrays. Studies are aimed in identifying differentially regulated genes and to characterize their functional relevance for conditions associated with atherosclerosis and to investigate molecular pathways by which the proteins encoded by these genes modulate disease processes. The work has led to the identification and characterization of a secretase-like protein which has been extensively studied in vitro and in vivo demonstrating that this protein is involved in the regulation of inflammation, cell growth, and atherogenesis.

Supported by SNSF grants Nr. 58 421, Nr. 58 426, Nr. 108 258 and Nr. 122 504
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Publications / Publikationen Glatzer C. Vascular genomics of human-like atherosclerosis: Identification of decorin by cDNA microarray. Dissertation, University of Zurich, 2006

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Keywords / Suchbegriffe atherosclerosis; vascular disease; risk factors; predisposition; genetic; inflammation; vascular reactivity; obesity; gender; sex differences;
Project leadership and contacts /
Projektleitung und Kontakte
Prof. Dr. Matthias Barton (Project Leader)
Funding source(s) /
Unterstützt durch
SNF (Personen- und Projektförderung)
In collaboration with /
In Zusammenarbeit mit
Prof. R. Brandes, University of Frankfurt Germany
Prof. K. Amann, University of Erlangen Germany
Dr. P. Cinelli, University of Zurich Switzerland
Duration of Project / Projektdauer Apr 2001 to Dec 2020