Jung

Fakultäten » Medizinische Fakultät » Neurologie, Klinik für » PD Dr. Hans H. Jung » Jung

Completed research project

Title / Titel	Magnetic resonance spectroscopy in CADASIL
PDF	Abstract (PDF, 14 KB)
Summary / Zusammenfassung	The phenotypic spectrum of the cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) encompasses transient ischaemic attacks and strokes, subcortical cognitive deficits, psychiatric disorders, and migraine with or without aura. The diagnosis of CADASIL may be suggested by personal history, positive family history, and the typical neuroradiological features. Definite diagnosis may be achieved by positive skin biopsy and/or molecular genetic testing of the notch-3 gene. Using spectroscopic and functional MR techniques, we want to further characterize the metabolic cerebral abnormalities in CADASIL patients. In addition, we want to investigate if the migraine pathophysiology in CADASIL patients differs from patients with common forms of migraine, and patients with other symptomatic forms of migraine such as mitochondrial cytopathies or familial hemiplegic migraine.
Project leadership and contacts / Projektleitung und Kontakte	PD Dr. Hans H. Jung (Project Leader) hans.jung@usz.ch PD Dr. Peter S. Sandor peter.sandor@usz.ch
Funding source(s) / Unterstützt durch	Foundation, Others
In collaboration with / In Zusammenarbeit mit	Prof. P. Boesiger Institute for Biomedical Engineering University of Zürich and Swiss Federal Institute of Technology Zürich Zürich, Switzerland Switzerland
Duration of Project / Projektdauer	May 2005 to May 2006