Straumann
Fakultäten » Medizinische Fakultät » Neurologie, Klinik für » Prof. Dr. Dominik Straumann » Straumann
Completed research project
| Title / Titel | Three-dimensional kinematical analysis of ocular motor disorders in humans | ||||||
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| Abstract (PDF, 14 KB) | |||||||
| Summary / Zusammenfassung | The long-term goal of this research (since 1998) is to better understand diseases of the ocular motor system in humans and to assess potential treatments. The focus of interest is on the three-dimensional (horizontal, vertical, torsional) kinematical properties of ocular rotations. Specifically, we explore eye movements in patients with (1) peripheral vestibular lesions, (2) cerebellar disorders, and (3) strabismus. While our previous work concentrated on analyzing mechanisms of the three-dimensional (3D) kinematical aberrations of the eyes, we now wish to evaluate adaptive procedures that potentially modify 3D eye rotations. In addition, we seek to identify and explain disorders in which the brain fails to solve the “tilt-translation dilemma”, i.e. is unable to distinguish between linear acceleration and gravity vector reorientation. Finally, we want to continue our long-term studies on the mechanisms of central compensation of 3D eye movements after acute vestibular lesions with or without therapeutic interventions, hereby concentrating on disorders of the translational vestibular-ocular reflex subsequent to lesions of the otolith organs. | ||||||
| Publications / Publikationen | Palla A, Straumann D, Obzina H (1999) Eye position dependence of three-dimensional ocular rotation axis orientation during head impulses in humans. Exp Brain Res 129: 127-133 Minor LB, Haslwanter T, Straumann D, Zee DS (1999) Hyperventilation-induced nystagmus in patients with vestibular Schwannoma. Neurology 53: 2158-2168 Schmid-Priscoveanu A, Straumann D, Böhmer A, Obzina H (1999) Vestibulo-ocular responses during static head roll and three-dimensional head impulses after vestibular neuritis. Acta Otolaryngol 119: 750-757 Straumann D, Zee DS, Solomon D (2000) Three-dimensional kinematics of ocular drift in humans with cerebellar atrophy. J Neurophysiol 83: 1125-1140 Lee C, Zee DS, Straumann D (2000) Saccades from torsional offset positions back to Listing’s plane. J Neurophysiol, 83: 3241-3253 Schmid-Priscoveanu A, Straumann D, Kori AA (2000) Torsional vestibulo-ocular reflex during whole-body oscillation in upright and supine position I. Responses in healthy human subjects. Exp Brain Res 134: 212-219 Brodsky MC, Haslwanter T, Kori AA, Straumann D (2000) The role of volitional effort in the Bielschowsky head tilt test: a clinical and oculographic assessment. Binocul Vis Strabismus Q 15, 325-330 Kori AA, Schmid-Priscoveanu A, Straumann D (2001) Vertical divergence and counterroll eye movements evoked by whole-body position steps about the roll axis of the head in humans. J Neurophysiol 85: 671–678 Bergamin O, Zee DS, Roberts DC, Landau K, Lasker AG, Straumann D (2001) Three-dimensional Hess screen test with binocular dual search coils in a three-field magnetic system. Invest Ophthalmol Vis Sci 42: 660-667 Bergamin O, Straumann D (2001) Three-dimensional binocular kinematics of torsional vestibular nystagmus during convergence on head-fixed targets in humans. J Neurophysiol 86: 113–122 Schmid-Priscoveanu A, Böhmer A, Obzina H, Straumann D (2001) Caloric and search-coil head impulse testing in patients after vestibular neuritis. J Ass Res Otolaryngol 2: 72-78 Bergamin O, Bizzarri S, Straumann D (2002) Ocular torsion during voluntary blinks in humans. Invest Ophthalmol Vis Sci: 3438–3443 Marti S, Palla A, Straumann D (2002) Gravity-dependence of ocular drift in patients with cerebellar downbeat nystagmus. Ann Neurol 52: 712–721 Bockisch CJ, Straumann D, Haslwanter T (2003) Eye movements during multi-axis whole-body rotations. J Neurophysiol 89: 355–366 Yakushin SB, Palla A, Haslwanter T, Bockisch CJ, Straumann D (2003) Gravity-dependent adaptation of the human vertical angular vestibulo-ocular reflex. Exp Brain Res 152:137-142 Solomon D, Zee DS, Straumann D (2003) Torsional and horizontal vestibular ocular reflex adaptation: three-dimensional eye movement analysis. Exp Brain Res, 152:150-155 Straumann D, Steffen H, Landau K, Bergamin O, Mudgil AV, Walker MF, Guyton DL, Zee DS (2003) Primary position and Listing’s law in acquired and congenital trochlear nerve palsy. Invest Ophthalmol Vis Sci 44: 4282-4292 Bergamin O, Ramat S, Straumann D, Zee DS (2004) Influence of orientation of exiting wire of search coil annulus on torsion following saccades. Invest Ophthalmol Vis Sci 45: 131-137 Weber KP, Landau K, Palla A, Haslwanter T, Straumann D (2004) Ocular rotation axes during dynamic Bielschowsky head-tilt testing in unilateral trochlear nerve palsy. Invest Ophthalmol Vis Sci 45: 455-65 Helmchen C, Sprenger A, Rambold H, Sander T, Kömpf D, Straumann D (2004) Effect of 3,4-diaminopyridine on the gravity dependence of ocular drift in downbeat nystagmus. Neurology 63: 752-753 Schmid-Priscoveanu A, Kori AA, Straumann D (2004) Torsional vestibulo-ocular reflex during whole-body oscillation in the upright and the supine position: II. Responses in patients after vestibular neuritis. J Vest Res, 14: 353-359 Palla A, Straumann D (2004) Recovery of the high-acceleration vestibulo-ocular reflex after vestibular neuritis. J Ass Res Otolaryngol 5: 427–435 Bockisch CJ, Straumann D, Haslwanter T (2004) The human 3D aVOR with and without otolith stimulation. Exp Brain Res 161: 358-67. Palla A, Marti S, Straumann D (2005) Head-shaking nystagmus depends on gravity. J Ass Res Otolaryngol 6: 1-8 Marti S, Bockisch CJ, Straumann D (2005) Prolonged asymmetric smooth pursuit stimulation leads to downbeat nystagmus in healthy human subjects. Invest Ophthalmol Vis Sci 46: 143-149 Ramat S, Straumann D, Zee DS (2005) The interaural translational VOR: suppression, enhancement and cognitive control. J Neurophysiol 94: 2391–2402 Palla A, Bockisch CJ, Bergamin O, Straumann D (2006) Dissociated hysteresis of static ocular counterroll in humans. J Neurophysiol 95 : 2222-2232 Marti S, Bockisch CJ, Straumann Dominik (2006) Asymmetric and symmetric and short-term adaptation of the vertical VOR in humans. Exp Brain Res: 172: 343-350 Sprenger A, Rambold H, Sander T, Marti S, Weber K, Straumann D, Helmchen C (2006) Treatment of the gravity-dependence of downbeat nystagmus with 3,4-diaminopyridine. Neurology 67: 905-907 Tarnutzer AA, Ramat S, Straumann D, Zee DS (2007) Pursuit responses to target steps during ongoing tracking. J Neurophysiol 97: 1266-79 Jorns-Häderli M, Straumann D, Palla A (2007) Accuracy of the bedside head-impulse test in detecting vestibular hypofunction. J Neurol Neurosurg Psychiatry, epub ahead of print |
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| Keywords / Suchbegriffe | eye movement disorders; humans; neuro-ophthalmology; neuro-otology;, neurology; three-dimensional ocular kinematics; otoliths; gravity; vestibulo-ocular reflex; rotation;, translation; adaptation | ||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Other links to external web pages | http://web.unispital.ch/neurologie/vest/homepages/straumann | ||||||
| Funding source(s) / Unterstützt durch |
SNF (Personen- und Projektförderung), Foundation, Private Sector (e.g. Industry) |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Sep 2004 to Aug 2007 |