Fakultäten » Medizinische Fakultät » Infektionskrankheiten und Spitalhygiene, Klinik für » Prof. Dr. Huldrych Günthard » Günthard

Completed research project

Title / Titel Linking the SmartGene and SHCS databases for developing a useful research tool
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung In 2000 the SHCS has decided to implement a database for genotypic resistance testing. All resistance laboratories in Switzerland are supposed to enter the sequence data obtained for routine genotypic resistance testing into this database. Linkage with the SHCS database has been difficult to achieve for a variety of reasons. It is thus at this point not possible to conduct scientific projects. For this reason, it is of utmost importance that the linkage between the two databases takes place as soon as possible. Thus, we propose a specific project to perform this linkage, to clean up the resistance database, to perform quality checks and to characterize the content of the linked databases descriptively. We will determine numbers of sequences available in the database with regards to specific patient groups. Descriptive characterization of the linked database is the prerequisite for further research projects using resistance data.
In conclusion, a considerable further effort is needed to transfer the resistance database into a useful research tool for the SHCS. Quality checks and a first inventory of it’s content will allow to conduct further research with this promising research tool.
Publications / Publikationen Haupts S, Ledergerber B, Böni J, Schüpbach J, Kronenberg A, Opravil M, Flepp M, Speck RF, Grube C, Rentsch K, Weber R, and Günthard HF, and the Swiss HIV Cohort Study. Impact of genotypic resistance testing on selection of salvage regimen in clinical practice. Antiviral Therapy. 2003;8:443-454.

Yerly S, Fagard C, Günthard HF, Hirschel B, Perrin L, and the Swiss HIV Cohort Study (SHCS). Selection of HIV-1 drug-resistance mutations during structured treatment interruptions. Antiviral Therapy. 2003;8:411-415.

Hasse B, Hummel Y, Böni J, Schüpbach J, Flepp M, Günthard H. [25-year-old therapy naive patient with 3 class resistant HIV infection]. 25-jähriger therapienaiver Patient mit einem dreiklassenresistenten HI-Virus. Schweizerische Rundschau Medizin (PRAXIS). 2003;92:601-605.

Keywords / Suchbegriffe HIV, drug resistance, genotypic drug resistance, database, swiss hiv cohort study,
Project leadership and contacts /
Projektleitung und Kontakte
Huldrych Günthard (Project Leader)
Bruno Ledergerber
Sabine Yerly
Funding source(s) /
Unterstützt durch
SNF (Personen- und Projektförderung), Others
Swiss HIV Cohort Study, Project No. 470
In collaboration with /
In Zusammenarbeit mit
Sabine Yerly, Luc Perrin,Laboratory of Virology, University of Geneva, Geneva

Thomas Klimkait, Institute of Microbiology, University of Basel, Basel

Phillip Bürgisser, Amalio Telenti, Martin Rickenbach, Yanik Valet, University of Lausanne, Lausanne
Jürg Böni, Jörg Schüpbach
Swiss National Center for Retroviruses, University of Zurich, Zurich
Sebastian Bonhoeffer,
Institute for Ecology, Swiss Federal Institute of Technology, Zurich
Duration of Project / Projektdauer Jun 2005 to Jun 2006