Fakultäten » Medizinische Fakultät » Infektionskrankheiten und Spitalhygiene, Klinik für » Prof. Dr. Huldrych Günthard » Günthard

Completed research project

Title / Titel Primary HIV-1 infection in Zurich
PDF Abstract (PDF, 14 KB)
Original title / Originaltitel Die akute HIV-Infektion in Zürich
Summary / Zusammenfassung Primary HIV-1 infection is often not recognized because of unspecific signs and symptoms of the acute retroviral syndrome. Nevertheless, it is of great importance that HIV-infection is detected early after infection to interrupt transmission chains and to monitor the transmission of drug resistant virus.
To obtain information on the local ongoing epidemic of HIV-1 primary infection in Zurich we are conducting a prospective longitudinal study enrolling patients with documented early HIV-infection.
We furthermore aim at describing symptoms and signs associated with the acute retroviral syndrom, will define factors which lead to a lag in diagnosing primary HIV-infection, determine subtype and mutational patterns associated with drug resistance of newly transmitted HIV-strains. Moreover, we are investigating whether early antiretroviral therapy results in a positive alteration of the disease course. Finally, we undertake intense studies of viral-host interactions, which are thought to be key to improve our understanding of HIV-1 pathogenesis.
Publications / Publikationen Hasse B, Hummel Y, Böni J, Schüpbach J, Flepp M, Günthard H. 25-jähriger therapienaiver Patient mit einem dreiklassenresistenten HI-Virus. Schweizerische Rundschau Medizin (PRAXIS). 2003;92:601-605.

Rusert P, Kuster H, Joos B, Misselwitz B, Gujer C, Leemann C, Fischer M, Stiegler G, Katinger H, Olson WC, Weber R, Aceto L, Günthard HF, Trkola A. Virus isolates during acute and chronic HIV infection show distinct pattern of sensitivity to entry inhibitors. Journal of Virology. 2005; (in press).

Aceto L, Karrer U, Grube C, Oberholzer R, Hasse B, Presterl E, Böni J, Kuster H, Trkola A, Weber R, Günthard HF. Die Akute HIV Infektion in Zürich: 2002 – 2004. Praxis 2005:(in press).

Keywords / Suchbegriffe acute HIV-1 infection, acute retroviral syndrome, primary hiv infection, antiretroviral therapy, virus host interactions, drug resistance, transmission
Project leadership and contacts /
Projektleitung und Kontakte
PD Dr. med. Huldrych Günthard (Project Leader)
Prof. Dr. med. Rainer Weber
Funding source(s) /
Unterstützt durch
Duration of Project / Projektdauer Jan 2002 to Dec 2007