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Günthard

Fakultäten » Medizinische Fakultät » Infektionskrankheiten und Spitalhygiene, Klinik für » Prof. Dr. Huldrych Günthard » Günthard

Completed research project

Title / Titel Humoral immunity to HIV-1: Analysis of the function of antibody responses as correlate and surrogate marker of viremia control
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung In this project, we will investigate the role of humoral immunity to HIV-1 in the pathogenesis of the infection. The overall aim of our proposal is to investigate the potency of the humoral immune response in controlling viremia. We aim do define the modes of antibody induction against HIV-1, the virus determined molecular correlates of humoral immunity, the protective potential of antibodies in vivo and investigate the feasibility of therapeutic vaccination based on humoral immunity.
Publications / Publikationen Trkola A, Kuster H, Leemann C, Ruprecht C, Joos B, Hirschel B, Weber R, Bonhoeffer S, Günthard HF, and the Swiss HIV cohort study. Cessation of antiretroviral treatment in chronic HIV-1 infection: Viral fitness is a determining factor of viral rebound and set point. Journal of Virology. 2003:77;13146-13155.

Trkola A, Kuster H, Leemann C, Ruprecht C, Joos B, Hirschel B, Weber R, Bonhoeffer S, Günthard HF, and the Swiss HIV cohort study. Cessation of antiretroviral treatment in chronic HIV-1 infection: Viral fitness is a determining factor of viral rebound and set point. Journal of Virology. 2003:77;13146-13155.

Rusert P, Kuster H, Joos B, Misselwitz B, Gujer C, Leemann C, Fischer M, Stiegler G, Katinger H, Olson WC, Weber R, Aceto L, Günthard HF, Trkola A. Virus isolates during acute and chronic HIV infection show distinct pattern of sensitivity to entry inhibitors. Journal of Virology. 2005; (in press).

Keywords / Suchbegriffe humoral immune response, HIV-1, neutralizing antibodies, therapeutic vaccination, HIV-1 pathogenesis, viremia
Project leadership and contacts /
Projektleitung und Kontakte
PD Dr. med. Huldrych Günthard (Project Leader) huldrych.guenthard@usz.ch
Prof. Dr. Alexandra Trkola alexandra.trkola@usz.ch
Funding source(s) /
Unterstützt durch
SNF (Personen- und Projektförderung)
 
Duration of Project / Projektdauer Mar 2004 to Feb 2007