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Günthard

Fakultäten » Medizinische Fakultät » Infektionskrankheiten und Spitalhygiene, Klinik für » Prof. Dr. Huldrych Günthard » Günthard

Completed research project

Title / Titel Evolution of the V3-loop of HIV-1 envelope from plasma of patients undergoing structured treatment interruptions
PDF Abstract (PDF, 14 KB)
Original title / Originaltitel Evolution der V3-Domäne von HIV-1 env aus Plasma von Patienten mit strukturierten Therapieunterbrüchen.
Summary / Zusammenfassung This project aims at defining the evolutionary characteristics of rebounding plasma HIV-1 viruses in patients undergoing structured treatment interruption after successful longterm antiretroviral therapy in relation to pretreatment viral quasispecies.
We are aiming at indentifying specific patterns of rebounding viruses with regards to viral diversity and coreceptor usage. In further steps, we will correlate virological findings with immunological parameters such as humoral and cellular immune responses in these patients.
Publications / Publikationen Günthard HF, Frost S, Leigh-Brown AJ, Ignacio CC, Kee K, Spina CA, Havlir DV, Hezareh M, Looney DJ, Richman DD, Wong JK. Evolution of envelope sequences of HIV-1 in cellular reservoirs in the setting of potent antiviral therapy. 1999. Journal of Virology. 1999; 73(11):9404-9412.

Trkola A, Kuster H, Leemann C, Ruprecht C, Joos B, Hirschel B, Weber R, Bonhoeffer S, Günthard HF, and the Swiss HIV cohort study. Cessation of antiretroviral treatment in chronic HIV-1 infection: Viral fitness is a determining factor of viral rebound and set point. Journal of Virology. 2003:77;13146-13155.

Trkola A, Kuster H, Leemann C, Oxenius A, Fagard C, Furrer H, Battegay M, Vernazza P, Bernasconi E, Weber R, Hirschel B, Bonhoeffer S, Günthard HF, and the Swiss HIV cohort study. Humoral immunity to HIV-1: Kinetics of antibody responses in chronic infection reflect capacity of immune system to improve viral set point. Blood. 2004;104:1784-1792.

Keywords / Suchbegriffe evolution, HIV-1, structured treatment interruption, antiretroviral treatment, envelope, V3-loop
Project leadership and contacts /
Projektleitung und Kontakte
PD Dr. med. Huldrych Günthard (Project Leader) huldrych.guenthard@usz.ch
Funding source(s) /
Unterstützt durch
Others
EMDO Stiftung
Duration of Project / Projektdauer Jul 2002 to Jul 2006