Latal Landolt
Fakultäten » Medizinische Fakultät » Kinderspital Zürich: Medizinische Klinik » Entwicklungspädiatrie, Abteilung » PD Dr. Oskar Jenni » Latal Landolt
Current research project
| Title / Titel | Health, neurodevelopment and quality of life in children before and after cardiac bypass surgery for congenital heart disease | ||||
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| Abstract (PDF, 14 KB) | |||||
| Summary / Zusammenfassung | Congenital heart disease (CHD) occurs in about 2-3 per thousand life births. There is evidence that despite good cardiac results after cardiac bypass surgery, neurodevelopmental outcome of these children may be impaired. A significant number of children display neurologic and behavioral abnormalities already before bypass surgery. Neuroimaging prior to surgery detected ischemic lesions and cerebral malformations in 24 percent of children with CHD. It is unclear how preexisting cerebral injury affects intraoperative vulnerability and ultimately longterm outcome. In addition, some children after bypass surgery for CHD are described to have behavorial difficulties, however without impairment of their quality of life. Psychosocial factors such as socioeconomic status, coping strategies and family stress may influence long term quality of life. It is unknown how psychosocial factors interact with medical risk factors, how they contribute to short and long-term outcome and in what extent they may be protective. The University Children's Hospital Zurich has become a center of competence for children with CHD. Approximately 200 to 250 children undergo cardiac bypass surgery annually. To better delineate the predictive value of medical and psychosocial variables, we are conducting a prospective cohort study on children with CHD who undergo cardiac bypass surgery by assessing health, neurodevelopmental status and psychosocial variables pre- and postoperatively. Currently, the study examines children at the age of 4 years and up to 6 years of age. |
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| Publications / Publikationen | Landolt MA, Valsangiacomo Buechel E, Latal B. (2008) Health-related quality of life in children and adolescents after open-heart surgery. J Pediatr, 152;349-55Helfricht S, Latal B, Fischer J, Tomaske M, Landolt MA. (2008) Surgery-related posttraumatic stress disorder in parents of children undergoing cardiopulmonary bypass surgery: a prospective cohort study. Pediatr Crit Care Med, 9:217-23Gessler P, Schmitt B, Prètre R, Latal B. (2009) Inflammatory response after open-heart surgery is related to neuromotor function in children with congenital heart disease. In press Pediatric Cardiology.Latal B, Helfricht S, Fischer J, Bauersfeld U, Landolt MA Psychological Adjustment and Quality of Life in Children and Young Adults after Open-Heart Surgery for Congenital Heart Disease: A Systematic Review, in press BMC PediatricsKnirsch W, Zingg W, Bernet V, Dimitropoulos, Balmer C, Beck I, Pretre R, Bauersfeld U, Latal B. Determinants of body weight gain and association with neurodevelopmental outcome in infants operated for congenital heart disease. Submitted to J Pediatr | ||||
| Keywords / Suchbegriffe | Congenital heart disease, child, bypass surgery, neurodevelopmental outcome, quality of life | ||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Foundation Mercator Foundation |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Feb 2008 to Jan 2015 |