Suter
Fakultäten » Vetsuisse-Fakultät » Virologisches Institut » Allgemein » Prof. Dr. Mark Suter » Suter
Completed research project
| Title / Titel | Flt3-L enhances resistance in neonates | ||||||
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| Abstract (PDF, 14 KB) | |||||||
| Summary / Zusammenfassung | Contents Resistance of newborn mice to HSV-1 and Listeria monocytogenes is increased 100-fold by treatment with the hematopoietic growth factor Flt3L. The resistance is coupled to the presence of IFN type I and IL-12 – cytokines responsible for the defense against HSV-1 and Listeria monocytogenes, respec-tively. Aims We would like to better understand the effect of Flt3L to different cells and their potential to induce immunological stimulation. Applications We evaluate the possibility to use or induce Flt3L in neonatal animals to enhance the immune responses. Summary 2004 This project was completet in 2004 with the publication: Vollstedt S., O'Keeffe M., Odermatt B., Glanzmann B., Riesen M., Shortman K., Suter M. (2004) Treatment of neonatal mice with Flt3L leads to chan-ges in Dc subpopulations associated with enhanced IL-12 and IFN-? production. Eur J Immunol 34: pp1849-1860. Weitere Informationen |
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| Publications / Publikationen | Vollstedt S., O'Keeffe M., Odermatt B., Glanzmann B., Riesen M., Shortman K., Suter M. (2004) Treatment of neonatal mice with Flt3L leads to chan-ges in Dc subpopulations associated with enhanced IL-12 and IFN-? production. Eur J Immunol 34: pp1849-1860.Weitere Informationen | ||||||
| Keywords / Suchbegriffe | newborn, listeria monocytogenes, cytokines, HSV-1, neonates | ||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
SNF (Personen- und Projektförderung), Private Sector (e.g. Industry) Bavarian Nordic, Immunex Corp. |
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| Duration of Project / Projektdauer | Nov 2001 to Dec 2004 |