Fakultäten » Vetsuisse-Fakultät » Labortierkunde, Institut für » Prof. Dr. Matthias Barton » Barton

Current research project

Title / Titel Pathomechanisms of cardiovascular injury in obesity
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Original title / Originaltitel Pathomechanismen durch Übergewicht bedingter arterieller Gefässchädigung
Summary / Zusammenfassung Obesity has become a major health concern in both Western and Eastern countries and is associated with an increased risk for atherosclerosis in general and in young people in particular. Our research in this area has focused on renal and vascular mechanisms which are associated with obesity. We have identified several pathways locally involved in the disease process. Recent work has shown that obesity idependently from blood pressure increases vasocontriction in an experimental model and that obesity also regulates renal angiotensin converting enzyme. Further research is in progress to determine novel therapeutic approaches to interfere with cardiovascular alterations promoting atherosclerosis development in obesity.

Supported by SNSF grants Nr. 58 421, Nr. 58 426, Nr. 108 258 and Nr. 122 504
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Publications / Publikationen Obesity causes lymphatic vascular injury: time for clinical translation
M. Barton, M. Husmann
J Physiol (Lond) 594, 6807-6808, 2016

Estrogens and coronary artery disease: new clinical perspectives
M.R. Meyer, M. Barton
Adv Pharmacol 77, 307-360, 2016

Not lost in translation: Emerging clinical importance of the G protein-coupled estrogen receptor GPER
M. Barton
Steroids 111, 37-45, 2016

Accelerated vascular aging as a paradigm for hypertensive vascular disease: prevention and therapy
M. Barton, M. Husmann, M.R. Meyer
Can J Cardiol 32, 680-686, 2016

Prostanoid-mediated contractions of the carotid artery become Nox2-independent with aging
M.R. Meyer, N.C. Fredette, M. Barton, E.R. Prossnitz
AGE 37, 79, 2015

Emerging roles of GPER in diabetes and atherosclerosis

M. Barton, E.R. Prossnitz

Trends Endocrinol Metab 26, 185-192, 2015

Estrogen biology: New insights on GPER function and clinical opportunities
E.R. Prossnitz, M. Barton
Mol Cell Endocrinol 389, 71-83, 2014

Obesity and heterozygous endothelial overexpression of prepro-endothelin-1 modulate responsiveness of mouse main and segmental renal arteries to vasoconstrictor agents
O. Baretalla, S.K. Chung, M. Barton, A. Xu, P.M. Vanhoutte
Life Sci 118, 206-212, 2014

Regulation of vascular smooth muscle tone by Adipose-Derived Contracting Factor
M.R. Meyer, N.C. Fredette, M. Barton, E.R. Prossnitz
PLoS ONE 8, e79245, 2013

Prevention and endothelial therapy of coronary artery disease
M. Barton
Curr Opin Pharmacol 13, 225-241, 2013

Mechanisms and therapy of atherosclerosis and its clinical complications
M. Barton
Curr Opin Pharmacol 13, 149-153, 2013

Cholesterol and atherosclerosis: Modulation by estrogen
M. Barton
Curr Opin Lipidol 24, 214-220, 2013

Childhood obesity: Preventing today's children from becoming tomorrow's patients 
M. Barton
IFAVA Scientific Newsletter 75, 1, 2013

Mechanisms and therapy of atherosclerosis and its clinical complications
M. Barton
Curr Opin Pharmacol 13, 149-153, 2013

Prevention and endothelial therapy of coronary artery disease
M. Barton
Curr Opin Pharmacol 13, 225-241, 2013

Childhood obesity: a life-long health risk
M. Barton
Acta Pharmacol Sin 33, 189-193, 2012

Obesity and risk of vascular disease: Importance of endothelium-dependent vasoconstriction
M. Barton, O. Baretella, M.R. Meyer
Br J Pharmacol 165, 591-602, 2012

The G protein-coupled estrogen receptor GPER in physiology and disease
E.R. Prossnitz, M. Barton
Nature Rev Endocrinol 7, 715-726, 2011

Obesity, insulin resistance and diabetes: sex differences and role of estrogens receptors
M.R. Meyer, D.J. Clegg, E.R. Prossnitz, M. Barton
Acta Physiol (Oxf) 203, 259-269, 2011

Obesity and aging: determinants of endothelial cell dysfunction and atherosclerosis
M. Barton
Pfugers Arch 460, 825-837, 2010

Childhood obesity induced by a high-fat diet causes premature vascular aging involving endothelium-dependent mechanisms
I. Bhattacharya, M. Damjanovic, A. Gut, S. Hager, A. Perez-Dominguez, R. Minotti, E. Haas, M. Barton
Hypertension 52: e89, 2008

Getting radical with obesity - New links between fat and heart disease
M. Barton, E. Haas, I. Bhattacharya.
Arterioscler Thromb Vasc Biol 29, 447-448, 2009

Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity
E. Haas, I. Bhattacharya, E. Brailoiu, M. Damjanovic, G.C. Brailoiu, X. Gao, L. Mueller-Guerre, A. Gut, R. Minotti, M.R. Meyer, K. Amann, E. Ammann, A. Perez-Dominguez, M. Genoni, D.J. Clegg, N.J. Dun, T.C. Resta, E.R. Prossnitz, M. Barton.
Circ Res 104, 288-291, 2009 (rapid report).

Fat intake and cardiovascular response.
M. Damjanovic, M. Barton
Curr Hypertens Rep 10, 25-31, 2008

Regional heterogeneity of functional changes in conduit arteries after high-fat diet
I. Bhattacharya, A.L. Mundy, C.C. Widmer, M.Kretz, M. Barton
Obesity 16, 743-748, 2008

Atherosklerotische Gefässerkrankungen und Stickstoffmonoxid (.NO): Die zunehmende Bedeutung von hoher Lebenserwartung und Übergewicht für die Klinik
M. Husmann, M. Keller, M. Barton
Swiss Med Forum 50, 1008-1011,2007

Effects on obesity on mortality in patients with unstable angina or non ST-elevation myocardial infarction
M. Barton, M. Husmann
Eur Heart J 28, 2950, 2007

Increased renal expression of SOD1 and decreased Nox2 expression after high-fat diet rich in lauric acid despite relative insulin resistance and weight gain.
E. Haas, A. Winklehner, I. Bhattacharya, R. Minotti, A.L. Mundy, C.C. Widmer, M. Damjanovic, M. Kretz, M. Barton
Hypertension 50, e136, 2007

Endothelin stimulates vascular hydroxyl radical formation: Effect of obesity.
AL Mundy, E. Haas, I. Bhattacharya, C.C. Widmer,M. Kretz, K. Baumann, M. Barton.
Am J Physiol Regul Integr Comp Physiol. 293, R2218-R2224, 2007

Fat intake modifies vascular responsiveness and receptor expression of vasoconstrictors: Implications for diet-induced obesity. A. L. Mundy, E. Haas, I. Bhattacharya, C.C. Widmer, M. Kretz, R. Hofmann-Lehmann, R. Minotti, M. Barton.
Cardiovasc Res 73, 368-75, 2007

Obesity-associated activation of angiotensin and endothelin in the cardiovascular system. Barton M, Carmona R, Ortmann J, Krieger JE, Traupe T.
Int J Biochem Cell Biol 35, 826-37, 2003

Cardiovascular consequences of the obesity pandemic: need for action. Barton M, Furrer J.
Exp Opin Invest Drugs 12, 1757-1759, 2003

Effects of obesity on endothelium-dependent reactivity during acute nitric oxide synthase inhibition: modulatory role of endothelin.Traupe T, D'Uscio LV, Muenter K, Morawietz H, Vetter W, Barton M.
Clin Sci (Lond) 103 (Suppl 48) 13S-15S, 2002

Obesity increases prostanoid-mediated vasosconstriction and vascular thromboxane receptor gene expression. Traupe T, Lang M, Goettsch W, Münter K, Morawietz H, Vetter W, Barton M .
J Hypertens 20(11):2239-45, 2002

Obesity is associated with tissue-specific activation of renal angiotensin-converting enzyme in vivo: evidence for a regulatory role of endothelin. Barton M, Carmona R, Morawietz H, d'Uscio LV, Goettsch W, Hillen H, Haudenschild CC, Krieger JE, Munter K, Lattmann T, Luscher TF, Shaw S.
Hypertension 35(1 Pt 2), 329-36, 2000

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Keywords / Suchbegriffe obesity, adipocyte, vascular, kidney, renal, angiotensin II, endothelin, prostanoids, endothelium-derived vasoconstrictor subtances, angiotensin converting enzyme, adipose
Project leadership and contacts /
Projektleitung und Kontakte
Prof. Dr. Matthias Barton (Project Leader)
Dr. Oliver Baretella  
Dr. Matthias Meyer  
Funding source(s) /
Unterstützt durch
SNF (Personen- und Projektförderung), Others
In collaboration with /
In Zusammenarbeit mit
Prof. J.E. Krieger, University of Sao Paulo Brazil
Prof. R. Hofmann-Lehmann, University of Zurich Switzerland
Prof. K. Amann, University of Erlangen Germany
Duration of Project / Projektdauer Mar 2005 to Dec 2020