Fakultäten » Vetsuisse-Fakultät » Labortierkunde, Institut für » Prof. Dr. Matthias Barton » Barton

Completed research project

Title / Titel Mechanisms of aging
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung Aging represents an independent risk factor cardiovascular and renal disease. Disease processes in the aging vasculature and kidney are thought to be multifactorial, including increased oxidative stress, apoptosis, and cellular injury. Recent research from our group has identified a disbalance between vasoactive factors responsible for inhibition and stimulation of cellular growth. Among these factors, endothelin-1, known as a potent vasoconstrictor, has been identified. Current research involves projects determining functional and biochemical alterations in the aged cardiovascular system and potential therapeutic approaches.
Publications / Publikationen Role of podocytes for reversal of glomerulosclerosis and proteinuria in the aging kidney after endothelin inhibition
J. Ortmann, K. Amann, R. P. Brandes, M. Kretzler, K. Münter, N. Parekh, T. Traupe, M. Lange, T. Lattmann, M. Barton
Hypertension 44:974-981, 2004

Aging and biomedicine 2005: Where should we go from here?
M. Barton
Cardiovasc Res 66, 187-189, 2005

Aging as a determinant of renal and vascular disease: role of endothelial factors
M. Barton
Nephrol Dial Transplant 20: 485-490, 2005

Anatomically distinct activation of endothelin-3 and the L-arginine/nitric oxide pathway in the kidney with advanced aging
T. Lattmann, S. Shaw, K. Münter, W. Vetter, M. Barton
Biochem Biophys Res Commun 327, 234–241, 2005

Early aging and anatomic heterogeneity determine cyclooxygenase-mediated vasoconstriction to angiotensin II in mice.
M. Kretz, A.L. Mundy, C.C. Widmer, M. Barton
J Cardiovasc Pharmacol 2006 48: 30-33

Endothelin ETA receptor blockade with darusentan increases sodium and potassium excretion in aging rats
T. Traupe, J. Ortmann, E. Haas, K. Münter, N. Parekh, R. Hofmann-Lehmann, K. Baumann, M. Barton
J Cardiovasc Pharmacol 47(3), 456-62, 2006

Hormone replacement therapy and atherosclerosis in postmenopausal women: does aging limit therapeutic benefits?
M. Barton, M.R. Meyer, E. Haas
Arterioscler Thromb Vasc Biol 2006 (in press)

Weitere Informationen

Keywords / Suchbegriffe aging, renal disease, atherosclerosis, glomerulosclerosis, vasculature,
Project leadership and contacts /
Projektleitung und Kontakte
PD Dr. Matthias Barton (Project Leader)
Dr. Thomas Lattmann  
Funding source(s) /
Unterstützt durch
SNF (Personen- und Projektförderung), Foundation, Others
In collaboration with /
In Zusammenarbeit mit
K. Amann, University of Erlangen Germany
M. Kretzler, University of Munich Germany
N. Parekh, University of Heidelberg Germany
Duration of Project / Projektdauer Apr 2002 to Mar 2006