Fakultäten » Vetsuisse-Fakultät » Labortierkunde, Institut für » Prof. Dr. Matthias Barton » Barton

Current research project

Title / Titel Functional and molecular characterization of atherogenesis
PDF Abstract (PDF, 14 KB)
Original title / Originaltitel Funktionelle und molekulare Charakterisierung der Atherogenese
Summary / Zusammenfassung This project investigates the development of spontaneous atherosclerosis due to severe hyperlipidemia on functional and structural injury. We will determine distribution of changes in different vascular beds, mediators involved, as well as specific structural alterations. The investigation will be performed in both males and females, and will cover the entire lifespan. It is expected to detect changes specific for gender and age, which may allow to improve therapy in selected populations.

Supported by SNSF grants Nr. 58 421, Nr. 58 426, Nr. 108 258 and Nr. 122 504
Weitere Informationen
Publications / Publikationen Estrogens and coronary artery disease: new clinical perspectives
M.R. Meyer, M. Barton
Adv Pharmacol 77, 307-360, 2016

Emerging roles of GPER in diabetes and atherosclerosis

M. Barton, E.R. Prossnitz

Trends Endocrinol Metab 26, 185-192, 2015

Prostanoid-mediated contractions of the carotid artery become Nox2-independent with aging
M.R. Meyer, N.C. Fredette, M. Barton, E.R. Prossnitz
AGE 37, 79, 2015

G protein-coupled estrogen receptor inhibits vascular prostanoid production and activity
M.R. Meyer, N.C. Fredette, M. Barton, E.R. Prossnitz
J Endocrinol 227, 61-69, 2015

G Protein-coupled estrogen receptor protects from atherosclerosis
M.R. Meyer, N.C. Fredette, T.A. Howard, C. Hu, C. Ramesh, C. Daniel, K. Ammann, J.B. Arterburn, M. Barton, E.R. Prossnitz.
Sci Rep 4, 7564, 2014

Balloon angioplasty - the legacy of Andreas Grüntzig, M.D. (1939-1985)
M. Barton, J. Grüntzig, M. Husmann, J. Rösch
Front Cardiovasc Med 1, 15, 2014

G Protein-coupled estrogen receptor protects from atherosclerosis
M. R. Meyer, N.C. Fredette, T.A. Howard, C. Hu, C. Ramesh, C. Daniel, K. Ammann, J.B. Arterburn, M. Barton, E.R. Prossnitz.
Sci Rep 4, 7564, 2014

Advancing and translating knowledge in vascular medicine
M. Husmann, M. Barton
Front Cardiovasc Med 1, 6, 2014

Aging and endothelin: determinants of disease
M. Barton
Life Sci 118, 97-109, 2014

Endothelin-1 but not angiotensin II contributes to functional aging in murine carotid arteries
M.R. Meyer, N.C. Fredette, M. Barton, E.R. Prossnitz
Life Sci 118, 213-218, 2014

Estrogen biology: New insights on GPER function and clinical opportunities
E.R. Prossnitz, M. Barton
Mol Cell Endocrinol 389, 71-83, 2014

Obesity and heterozygous endothelial overexpression of prepro-endothelin-1 modulate responsiveness of mouse main and segmental renal arteries to vasoconstrictor agents
O. Baretalla, S.K. Chung, M. Barton, A. Xu, P.M. Vanhoutte
Life Sci 118, 206-212, 2014

Functional heterogenity of NADPH oxidase-mediated contractions to endothelin with vascular aging
M.R. Meyer, M. Barton, E.R Prossnitz
Life Sci 118, 226-231, 2014

Regulation of vascular smooth muscle tone by Adipose-Derived Contracting Factor
M.R. Meyer, N.C. Fredette, M. Barton, E.R. Prossnitz
PLoS ONE 8, e79245, 2013

Endothelin in coronary artery disease and myocardial infarction
T.M. Kolettis, M. Barton, D. Langleben, Y. Matsumura
Cardiol Rev 24, 124-220, 2013

Cholesterol and atherosclerosis: Modulation by estrogen
M. Barton
Curr Opin Lipidol 24, 214-220, 2013

Prevention and endothelial therapy of coronary artery disease
M. Barton
Curr Opin Pharmacol 13, 225-241, 2013

Mechanisms and therapy of atherosclerosis and its clinical complications
M. Barton
Curr Opin Pharmacol 13, 149-153, 2013

Position paper: The membrane estrogen receptor GPER - Clues and questions
M. Barton
Steroids 77, 935-942, 2012

Deletion of the G protein-coupled estrogen receptor increases endothelial vasoconstriction
M.R. Meyer, K. Amann, A.S. Field, C. Hu, H.J. Hathyway, N.L. Kanagy, M.K. Walker, M. Barton, E.R. Prossnitz
Hypertension 59, 507-512, 2012

Childhood obesity: a life-long health risk
M. Barton
Acta Pharmacol Sin 33, 189-193, 2012

Obesity and risk of vascular disease: Importance of endothelium-dependent vasoconstriction
M. Barton, O. Baretella, M.R. Meyer
Br J Pharmacol 165, 591-602, 2012

GPER regulates endothelin-dependent vascular tone and intracellular calcium
M.R. Meyer, A.S. Field, N.L. Kanagy, M. Barton, E.R. Prossnitz
Life Sci epub Feb 2, 2012

Testosterone and secondary hypertension: New pieces to the puzzle
M. Barton, E.R. Prossnitz, M.R. Meyer
Hypertension 59, 1011-1103, 2012

Obesity, insulin resistance and diabetes: sex differences and role of estrogens receptors
M.R. Meyer, D.J. Clegg, E.R. Prossnitz, M. Barton
Acta Physiol (Oxf) 203, 259-269, 2011

GPER/GPR30 and regulation of vascular tone and blood pressure
M.R. Meyer, E.R. Prossnitz, M. Barton
Immunol Endocr Metab Agents Med Chem 4, 255-261, 2011

The G protein-coupled estrogen receptor GPER in physiology and disease
E.R. Prossnitz, M. Barton
Nature Rev Endocrinol 7, 715-726, 2011

The G protein-coupled estrogen receptor GPER/GPR30 as a regulator of cardiovascular function
M.R. Meyer, E.R. Prossnitz, M. Barton
Vascul Pharmacol 55, 17-25, 2011

M.R. Meyer, O. Baretella, E.R. Prossnitz, M. Barton. Dilation of epicardial coronary arteries by the G protein-coupled estrogen receptor agonists G-1 and ICI 182,780
Pharmacology 86, 58-64, 2010

Obesity and aging: determinants of endothelial cell dysfunction and atherosclerosis
M. Barton
Pflügers Arch Eur J Physiol 460, 825-837, 2010

M.R. Meyer, M. Barton.
ERα, ERβ, and gpER: Novel aspects of estrogen receptor signaling in atherosclerosis
Cardiovasc Res 83, 605-610, 2009

M.R. Meyer, E. Haas, M. Barton.
Need for research on estrogen receptor function: Importance for hormone replacement therapy and atherosclerosis
Gend Med 5, S10-S22, 2008

Differential effects of 17β-estradiol on function and expression of estrogen receptor α, estrogen receptor β, and GPR30 in arteries and veins of patients with atherosclerosis.
E. Haas, M.R. Meyer, U. Schurr, I. Bhattacharya, R. Minotti, H.H. Nguyen, A. Heigl, M. Lachat, M. Genoni, M. Barton.
Hypertension 49, 1358-1363, 2007

Antioxidant activity and gender differences of acute vascular effects of amiodarone in advanced atherosclerosis
T. Traupe, M. Keller, E. Fojtu, I. Bhattacharya, M. Lang, H.R. Ha, A.L. Mundy, M. Barton.
J Cardiovasc Pharmacol 50, 578-584, 2007

M.J. Husmann, M. Barton.
Therapeutic potential of direct thrombin inhibitors for atherosclerotic vascular disease.
Exp Opin Invest Drugs 16, 563-567, 2007

M. Barton. R. Minotti, E. Haas.
Inflammation and atherosclerosis.
Circ Res 101, 750-751, 2007

M. Husmann, M. Keller, M. Barton.
Artériopathies athérosclerotiques et monoxyde d’azote (NO): de L’obésité et l’importance clinique d’une espérance de vie plus longue
Forum Médical Suisse 50, 1008-1011, 2007

Traupe T, Ortmann J, Munter K, Barton M
Endothelial therapy of atherosclerosis and its risk factors.
Current Vasc Pharmacol 1, 111-121, 2003

Endothelin, hypercholesterolemia, and Atherosclerosis
Barton M, Traupe T, Haudenschild CC
Coron Artery Dis 14, 477-490, 2003

Traupe T, Lang M, Goettsch W, Münter K, Morawietz H, Vetter W, Barton M
Obesity increases prostanoid-mediated vasosconstriction and vascular thromboxane receptor gene expression
J Hypertens 20(11):2239-45, 2002.

Weitere Informationen

Keywords / Suchbegriffe atherosclerosis, endothelium, vascular function, nitric oxide, endothelin, plaque, relaxation, heterogeneity, gender, sex differences
Project leadership and contacts /
Projektleitung und Kontakte
Prof. Dr. Matthias Barton (Project Leader)
Dr Matthias Meyer  
Funding source(s) /
Unterstützt durch
SNF (Personen- und Projektförderung), Foundation, Others
In collaboration with /
In Zusammenarbeit mit
Prof. C.C. Haudenschild, George Washington University Medical Center, Washington D.C.
Prof. E. Prossnitz, University of New Mexico, Albuquerque
United States
Prof. E. Falk, University of Aarhus Denmark
Prof. R.P. Brandes, University of Frankfurt Germany
Duration of Project / Projektdauer Apr 2000 to Dec 2020