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Barton

Fakultäten » Vetsuisse-Fakultät » Labortierkunde, Institut für » Prof. Dr. Matthias Barton » Barton

Completed research project

Title / Titel Hormone replacment therapy and atherosclerosis
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung Endogenous estrogens have been implicated in primary prevention of atherosclerosis in premenopausal women and lack of estrogen is an associated with an increased risk to develop coronary artery disease in men. Observational studies have suggested that estrogen replacement therapy may reduce the risk for coronary artery disease. These data have been recently challenged by large-scale clinical studies (ERA, HERS, HERS II, WHI) using equine estrogens and methoxyprogesteroneacetate (MPA) replacement therapy in postmenopausal women with increased risk for cardiovascular disease. These studies turned out to be negative and showed an increased risk for subsequent cardiovascular events and thrombosis. The goal of our research is to define responses to and functions of estrogen receptors in the human vasculature in health and during atherogenesis.

Data acquisition of this project is finished. A follow-up project entitled "Molecular mechanisms of estrogen-mediated vascular protection" has recently been started which is aimed at defining receptor function and pathways involved.
Publications / Publikationen Postmenopausal hormone-replacement therapy
Barton M, Dubey R
N Engl J Med 2002; 346:63-5

Ortal contraceptives and the risk of thrombosis and atherosclerosis
Barton M, Dubey, RK, Traupe, T.
Ex Opin Invest Drugs 2002, 11(3), 329-32

Einfluss Postmenopausaler Hormonsubstitution mit konjugierten equinen Oestrogenen und Medroxyprogesteronazetat auf das kardiovaskuläre Risiko
J. Ortmann, W. Vetter, T. Traupe, M. Barton
Schweiz Runsch Med (PRAXIS) 93:904-914 904, 2004

Vascular consequences of menopause and hormone therapy: Importance of timing of treatment and type of estrogen
R. K. Dubey, B. Imthurn, M. Barton, E.K. Jackson
Cardiovasc Res 66, 295- 306, 2005

Gender differences of cardiovascular disease: New perspectives for estrogen receptor signaling
M.M. Meyer, E. Haas, M. Barton
Hypertension 47, 1019-26, 2006

Hormone replacement therapy and atherosclerosis in postmenopausal women: does aging limit therapeutic benefits?
M. Barton, M.R. Meyer, E. Haas
Arterioscler Thromb Vasc Biol 2006 (in press)

Weitere Informationen

Keywords / Suchbegriffe vascular, atherosclerosis, estrogen, muscle, endothelium, receptor, hormone replacement therapy,
Project leadership and contacts /
Projektleitung und Kontakte
PD Dr. Matthias Barton (Project Leader) barton@access.uzh.ch
Matthias Lang  
Dr. Tobias Traupe  
Serafino Forte  
Funding source(s) /
Unterstützt durch
SNF (Personen- und Projektförderung), Foundation, Others
 
In collaboration with /
In Zusammenarbeit mit
R.K. Dubey, Endocrinology, Obst & Gyn, University Hospital Zurich Switzerland
M. Lachat, Vascular Surgery, University Hospital Zurich Switzerland
Duration of Project / Projektdauer Apr 2000 to May 2006