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Completed research project

Title / Titel Immunomodulatory functions of endothelin
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung Endothelin was originally discovered as a vasoconstrictor protein released from vascular endothelial cells. Subsequent studies have shown that this peptide is not only involved in vasomotion, but importantly contributes to cellular proliferation, endocrine function, inflammation, and carcinogenesis. We are currently investigating the contribution of endothelin to inflammatory and immunological responses in infectious diseases, chronic rejection, and related immune conditions.
Weitere Informationen
Publications / Publikationen Role of endothelin during experimental Trypanosoma Cruzi infection in rats.
E.R.S. Camargos, A. L. Teixeira-Jr, C. R.S. Machado, A.P. Almeida, M. Barton, M. M.Teixeira.
Clin Sci (Lond), 103(S), 64S-7S, 2002

Protective Role of ETA endothelin receptors during the acute phase of Trypanosoma cruzi infection in rats
E.R. Camargos, L.L. Rocha, M.A. Rachid, A.P. Almeida, A.J. Ferreira, A.L. Teixeira-Jr, E. Chiari, M. Barton, M.M. Teixeira, C.R Machado
Microbes and Infection 6, 650–656, 2004

Upregulation of vascular ETB receptor gene expression after chronic ETA receptor blockade in prediabetic NOD mice
J. Ortmann, T. Traupe, P. Nett, J. Celeiro, R. Hofmann-Lehmann, M. Lange, W. Vetter, M. Barton
J Cardiovasc Pharmacol 44, S105-108, 2004

Activation of pro-inflammatory and anti-inflammatory cytokines in host organs during chronic allograft rejection: Role of endothelin receptor signaling
T. Lattmann, M. Hein, S. Horber, J. Ortmann, M. M. Teixeira, D. G. Souza, E. Haas, L. Tornillo, K. Münter, W. Vetter, M. Barton
Am J Transplant 5, 1042 - 1049, 2005

Endothelin inhibition delays onset of hyperglycemia and associated vascular injury in type I diabetes: Evidence for endothelin release by pancreatic islet beta-cells.
J. Ortmann, P.C. Nett, J. Celeiro, T. Traupe, L. Tornillo, R. Hofmann-Lehmann, E. Haas, B. Frank, L.M. Terraciano, M. Barton
Biochem Biophys Res Commun. 334, 689-695, 2005

Recent developments of endothelin antagonists as inmmunomodulatory drugs – from infection to transplantation medicine. P.C. Nett, M.M. Teixeira, D. Candinas, M. Barton.
Recent Patent Review Cardiovasc Drug Discov 1, 233-244, 2006

Down-regulation of renal endothelin converting enzyme-2 expression in early autoimmune diabetes
J. Ortmann, P.C. Nett, J. Celeiro, R. Hofmann-Lehmann, L. Tornillo, L. Terraciano, M. Barton
Exp Biol Med 231(6), 1030-3, 2006

Upregulation of endothelin converting enzyme-1 in host liver during chronic cardiac allograft rejection.
T. Lattmann, J. Ortmann, S. Horber, M. Hein, S.G. Shaw, M. Barton.
Exp Biol Med 231(6), 899-901, 2006

Transcriptional regulation of vascular bone morphogenetic protein by endothelin receptors in early autoimmune diabetes mellitus
P.C. Nett, J. Ortmann, J. Celeiro, E. Haas, R. Hofmann-Lehmann, L. Tornillo, L.M. Terraciano, M. Barton
Life Sciences 78 (19), 2213-8, 2006

Keywords / Suchbegriffe endothelin, chagas, interleukin, inflammation, heart, myocardium, transplantation, rejection, autoimmune disease, insulitis
Project leadership and contacts /
Projektleitung und Kontakte
PD Dr. Matthias Barton (Project Leader)
Dr. Thomas Lattmann  
Dr. Elvira Haas  
Sybille Horber  
Funding source(s) /
Unterstützt durch
Forschungskredit der Universität Zürich, SNF (Personen- und Projektförderung), Foundation, Others
In collaboration with /
In Zusammenarbeit mit
M.M. Teixeira, University of Minas Gerais, Belo Horizonte Brazil
M. Hein, University of Aachen Germany
Duration of Project / Projektdauer Apr 1999 to Mar 2006