Hess
Fakultäten » Medizinische Fakultät » Neurologie, Klinik für » Prof. Dr. Bernhard Hess » Hess
Completed research project
| Title / Titel | Neuronal organization of otolith-ocular reflexes | ||||
|---|---|---|---|---|---|
| Abstract (PDF, 14 KB) | |||||
| Summary / Zusammenfassung | Our sense of motion emerges from central processing of sensory signals originating from the vestibular organs and their interactions with visual and somatosensory proprioceptive signals. The vestibular organs which are exquisitely sensitive to angular and linear accelerations of the head are located in the base of the skull. They provide the most important input to an intricate neuronal machinery located in the brainstem and the cerebellum which is involved in controlling eye, head and body posture and movements. Vestibular research aims at a better understanding of the basic mechanisms that underlie neural processing of motion signals at the brainstem level and the cerebellum. Higher order signal processing occur in the thalamus and in cortical projection areas that ultimately lead to a percept of motion. In recent years, we have studied the central interaction of afferent signals originating from the two main vestibular organs, the semicircular canals which detect angular head acceleration and the otolith organs which respond to gravito-inertial acceleration associated with head orientation (relative to gravity) and linear displacements. We found that otolith signals are essential in establishing an inertial reference frame which plays a crucial role in controlling self-motion and spatial orientation (independent of vision). At the basis of inertial signal processing is an algorithm that allows the system to distinguish very rapidly head (and body) tilts from translatory displacements, despite the ambiguous nature of the otolith afferent signals. We are now starting a project of single unit recording which aims at determining the mechanisms of inertial signal processing in the brainstem and vestibulo-cerebellum of primates at the neuronal level. Further research topics have been 3D spatial organization of vestibulo-ocular reflexes (VOR), mechanisms of VOR cross-axis adaptation, adaptation of 3D VOR following alterations of the sensory organs. | ||||
| Publications / Publikationen | Angelaki, D. E.; Hess, B. J. Self-motion-induced eye movements: effects on visual acuity and navigation. Nat. Rev. Neurosci. 2005, 6 (12), 966-976. Hess, B. J.; Jaggi-Schwarz, K.; Misslisch, H. Canal-otolith interactions after off-vertical axis rotations. II. Spatiotemporal properties of roll and pitch postrotatory vestibuloocular reflexes. J Neurophysiol 2005, 93 (3), 1633-1646. Lorincz, E. N.; Hess, B. J. Do perception and postrotatory vestibulo-ocular reflex share the same gravity reference? Journal of Gravitational Physiology 2005, 12 (1), P-25-P-26. Mandelli, M. J.; Misslisch, H.; Hess, B. J. Static and dynamic properties of vergence-induced reduction of ocular counter-roll in near vision. Eur. J Neurosci. 2005, 21 (2), 549-555. Angelaki, D. E.; Hess, B. J. Control of eye orientation: where does the brain's role end and the muscle's begin? Eur. J Neurosci 2004, 19 (1), 1-10. Hess, B. J.; Angelaki, D. E. Vestibular contributions to gaze stability during transient forward and backward motion. J. Neurophysiol. 2003, 90 (3), 1996-2004. Hess, B. J.; Angelaki, D. E. Dynamic modulation of ocular orientation during visually guided saccades and smooth-pursuit eye movements. Ann. N. Y. Acad. Sci. 2003, 1004, 132-141. Hess, B. J.; Angelaki, D. E. Dynamic modulation of ocular orientation during visually guided saccades and smooth-pursuit eye movements. Ann N Y Acad Sci 2003, 1004, 132-141. Hess, B. J.; Angelaki, D. E. Gravity modulates Listing's plane orientation during both pursuit and saccades. J. Neurophysiol. 2003, 90 (2), 1340-1345. Angelaki, D. E.; Hess, B. J. Direction of heading and vestibular control of binocular eye movements. Vision Res. 2001, 41 (25-26), 3215-3228. Hess, B. J. Vestibular signals in self-orientation and eye movement control. News Physiol Sci. 2001, 16, 234-238. Misslisch, H.; Tweed, D.; Hess, B. J. Stereopsis outweighs gravity in the control of the eyes. J. Neurosci. 2001, 21 (3), RC126. Angelaki, D. E.; Merfeld, D. M.; Hess, B. J. Low-frequency otolith and semicircular canal interactions after canal inactivation. Exp. Brain Res. 2000, 132 (4), 539-549. Angelaki, D. E.; McHenry, M. Q.; Hess, B. J. Primate translational vestibuloocular reflexes. I. High-frequency dynamics and three-dimensional properties during lateral motion. J. Neurophysiol. 2000, 83 (3), 1637-1647. Hess, B. J.; Lysakowski, A.; Minor, L. B.; Angelaki, D. E. Central versus peripheral origin of vestibuloocular reflex recovery following semicircular canal plugging in rhesus monkeys. J Neurophysiol. 2000, 84 (6), 3078-3082. Jaggi-Schwarz, K.; Misslisch, H.; Hess, B. J. Canal-otolith interactions after off-vertical axis rotations I. Spatial reorientation of horizontal vestibuloocular reflex. J. Neurophysiol. 2000, 83 (3), 1522-1535. Misslisch, H.; Hess, B. J. Three-dimensional vestibuloocular reflex of the monkey: optimal retinal image stabilization versus listing's law. J. Neurophysiol. 2000, 83 (6), 3264-3276. Otolith function in spatial orientation and movement: Symposium in memory of Volker Henn. Zurich, Switzerland, May 18-19, 1998. Proceedings; 871 ed.; Cohen, B.; Hess, B. J., editors; New York Academy of Science: New York, 1999. Angelaki, D. E.; McHenry, M. Q.; Dickman, J. D.; Newlands, S. D.; Hess, B. J. Computation of inertial motion: neural strategies to resolve ambiguous otolith information. J. Neurosci. 1999, 19 (1), 316-327. Hess, B. J.; Angelaki, D. E. Oculomotor control of primary eye position discriminates between translation and tilt. J. Neurophysiol. 1999, 81 (1), 394-398. Hess, B. J.; Angelaki, D. E. Inertial processing of vestibulo-ocular signals. Ann. N. Y. Acad. Sci. 1999, 871, 148-161. Jaggi-Schwarz, K.; Misslisch, H.; Hess, B. J. Inertial transformation of 3D eye velocity after off-vertical axis rotations. In Proceedings of the IVth International Symposium on the Head/Neck System, Tokyo Medical University Hospital: Tokyo, Japan, 1999. McHenry, M. Q.; Hess, B. J.; Angelaki, D. E. Three-dimensional primate eye movements during lateral translation. In Current Oculomotor Research: Physiological and Psychophysical Aspects, Becker, W., Deubel, H., Mergner, T., Eds.; Plenum Press: 1999; pp 117-124. Angelaki, D. E.; Hess, B. J. Visually induced adaptation in three-dimensional organization of primate vestibuloocular reflex. J. Neurophysiol. 1998, 79 (2), 791-807. Hess, B. J.; Angelaki, D. E. Kinematic principles of primate rotational vestibulo-ocular reflex. I. Spatial organization of fast phase velocity axes. J. Neurophysiol. 1997, 78 (4), 2193-2202. Hess, B. J.; Angelaki, D. E. Inertial vestibular coding of motion: concepts and evidence. Curr Opin Neurobiol 1997, 7 (6), 860-866. Hess, B. J.; Angelaki, D. E. Kinematic principles of primate rotational vestibulo-ocular reflex. II. Gravity-dependent modulation of primary eye position. J. Neurophysiol. 1997, 78 (4), 2203-2216. Hess, B. J.; Angelaki, D. E. Inertial vestibular coding of motion: concepts and evidence. Curr. Opin. Neurobiol. 1997, 7 (6), 860-866. Angelaki, D. E.; Hess, B. J. Adaptation of primate vestibuloocular reflex to altered peripheral vestibular inputs. II Spatiotemporal properties of the adapted slow- phase eye velocity. J. Neurophysiol. 1996, 76 (5), 2954-2971. Angelaki, D. E.; Hess, B. J. Organizational principles of otolith- and semicircular canal-ocular reflexes in rhesus monkeys. Ann. N. Y. Acad. Sci. 1996, 781, 332-347. Angelaki, D. E.; Hess, B. J. Three-dimensional organization of otolith-ocular reflexes in rhesus monkeys. II. Inertial detection of angular velocity. J Neurophysiol 1996, 75 (6), 2425-2440. Angelaki, D. E.; Hess, B. J. Three-dimensional organization of otolith-ocular reflexes in rhesus monkeys. I. Linear acceleration responses during off-vertical axis rotation. J Neurophysiol 1996, 75 (6), 2405-2424. Angelaki, D. E.; Hess, B. J.; Arai, Y.; Suzuki, J. Adaptation of primate vestibuloocular reflex to altered peripheral vestibular inputs. I. Frequency-specific recovery of horizontal VOR after inactivation of the lateral semicircular canals. J Neurophysiol 1996, 76 (5), 2941-2953. Angelaki, D. E.; Hess, B. J. Adaptation of primate vestibuloocular reflex to altered peripheral vestibular inputs. II Spatiotemporal properties of the adapted slow-phase eye velocity. J Neurophysiol 1996, 76 (5), 2954-2971. Angelaki, D. E.; Hess, B. J.; Suzuki, J. Differential processing of semicircular canal signals in the vestibulo- ocular reflex. J. Neurosci. 1995, 15 (11), 7201-7216. Angelaki, D. E.; Hess, B. Vestibulo-ocular control by the cerebellar nodulo-uvular lobules. In Information processing underlying gaze control, Delgado-Garcia, J. M., Godaux, E., Vidal, P. P., Eds.; Pergamon: 1995; pp 403-413. Angelaki, D. E.; Hess, B. J. Inertial representation of angular motion in the vestibular system of rhesus monkeys. II. Otolith-controlled transformation that depends on an intact cerebellar nodulus. J. Neurophysiol. 1995, 73 (5), 1729-1751. Angelaki, D. E.; Hess, B. J. Lesion of the nodulus and ventral uvula abolish steady-state off- vertical axis otolith response. J. Neurophysiol. 1995, 73 (4), 1716-1720. Hess, B. J.; Angelaki, D. E. Inertial representation of visual and vestibular self-motion signals. In Multisensory control of posture, Mergner, T., Hlavacka, F., Eds.; Plenum Press: New York, London, 1995; pp 183-190. Angelaki, D. E.; Hess, B. J. The cerebellar nodulus and ventral uvula control the torsional vestibulo-ocular reflex. J. Neurophysiol. 1994, 72 (3), 1443-1447. Angelaki, D. E.; Hess, B. J. Inertial representation of angular motion in the vestibular system of rhesus monkeys. I. Vestibuloocular reflex. J. Neurophysiol. 1994, 71 (3), 1222-1249. Hess, B. J.; Angelaki, D. E. Angular velocity detection by head movements orthogonal to the plane of rotation. Exp Brain Res 1993, 95 (1), 77-83. Hess, B. J.; Angelaki, D. E. Modelling spatiotemporal properties of directionally sensitive multi-input single-output systems. Biol. Cybern. 1993, 69 (5-6), 407-414. Haslwanter, T.; Straumann, D.; Hess, B. J.; Henn, V. Static roll and pitch in the monkey: shift and rotation of Listing's plane. Vision Res. 1992, 32 (7), 1341-1348. Haslwanter, T.; Straumann, D.; Hess, B. J.; Henn, V. Does counterrolling violate Listing's law? Ann. N. Y. Acad. Sci. 1992, 656, 931-932. Hess, B. J. How does the otolith system detect three-dimensional head angular velocity? Ann. N. Y. Acad. Sci. 1992, 656, 850-853. Hess, B. J. Three-dimensional head angular velocity detection from otolith afferent signals. Biol. Cybern. 1992, 67 (4), 323-333. Hess, B. J.; Van Opstal, A. J.; Straumann, D.; Hepp, K. Calibration of three-dimensional eye position using search coil signals in the rhesus monkey. Vision Res 1992, 32 (9), 1647-1654. |
||||
| Keywords / Suchbegriffe | 3D eye and head movements, vestibulo-ocular reflex, inertial vestibular system, visual-vestibular interaction, vestibulo-cerebellum | ||||
| Project leadership and contacts / Projektleitung und Kontakte |
|
||||
| Funding source(s) / Unterstützt durch |
SNF (Personen- und Projektförderung), Foundation Betty & David Koetser Foundation for Brain Research |
||||
| In collaboration with / In Zusammenarbeit mit |
|
||||
| Duration of Project / Projektdauer | Apr 1992 to Sep 2007 |