Jung
Fakultäten » Medizinische Fakultät » Neurologie, Klinik für » PD Dr. Hans H. Jung » Jung
Completed research project
| Title / Titel | Amyotrophic lateral sclerosis (ALS) in Switzerland: clinical characteristics, molecular background and biological markers. | ||||
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| Abstract (PDF, 14 KB) | |||||
| Summary / Zusammenfassung | ALS occurs throughout the world with no racial, ethnic or socioeconomic boundaries. Most people who develop ALS are between the ages of 40 and 70, although the disease can occur at a younger age. Incidence and prevalence rates have increased steadily between the 1960s and 1980s, actually ranging from 1.47 to 2.5 per 100000/year. ALS may affect as many as 400 Swiss people with 100-150 new cases diagnosed each year. About 15 to 20 percent of ALS cases are thought to be inherited, about 80 percent of them as a dominant trait. The clinical and pathological characteristics of familial ALS (FALS) and sporadic ALS (SALS) are almost identical. At present, at least 8 gene loci are known to be associated with different types of ALS, and 2 genes have been identified: copper zinc superoxide dismutase 1 (SOD1) on chromosome 21q22, and ALSIN on chromosome 2q33. We want to prospectively investigate the clinical characteristics of Swiss ALS patients, determine their molecular background in respect to mutations of known candidate genes, and collect CSF sample for future determinatin of biological markers. |
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| Keywords / Suchbegriffe | ALS, notoneuron disease, SOD, Alsin | ||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Forschungskredit der Universität Zürich, Others |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Jan 2003 to Dec 2008 |