Bombeli
Fakultäten » Medizinische Fakultät » Hämatologie, Klinik für » Prof. Dr. Jörg Fehr (emeritiert) » Bombeli
Completed research project
| Title / Titel | Decreased anticoagulant response to tissue factor pathway inhibitor in patients with venous thrombo-embolism and otherwise no evidence of hereditary or acquired thrombophilia | ||||
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| Abstract (PDF, 14 KB) | |||||
| Summary / Zusammenfassung | Although tissue factor pathway inhibitor (TFPI) is a po-tent natural anticoagulant that effectively inhibits factor Xa and factor VIIa, no relevant quantitative or qualitative deficiency of TFPI has thus far been reported that could be associated with venous thrombosis. In addition, none of the three known TFPI genetic poly-morphisms could be established as a significant risk factor for venous thrombosis. Based on these observations, we have therefore cre-ated a novel TF-based clotting assay that evaluated the anticoagulant response to exogenously added recombinant TFPI. Using this test, we found that in patients with a history of thrombosis but exclusion of known thrombophilia, the prevalence of a reduced response to TFPI is much higher than in healthy persons. Based on these results, a reduced response to TFPI may lead to a remarkably increased risk of venous thrombosis. |
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| Publications / Publikationen | Bombeli T, Piccapietra B, Boersma J, Fehr J. Decreased anticoagulant re-sponse to tissue factor pathway inhibi-tor in patients with venous thromboem-bolism and otherwise no evidence of hereditary or acquired thrombophilia. Thrombosis & Haemostasis 2004;91:80 |
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| Keywords / Suchbegriffe | tissue factor pathway inhibitor, anticoagulant response, thrombophilia | ||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Other Public Sources (e.g. Federal or Cantonal Agencies) |
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| Duration of Project / Projektdauer | Sep 2001 to Dec 2004 |