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Günthard Trkola

Fakultäten » Medizinische Fakultät » Infektionskrankheiten und Spitalhygiene, Klinik für » Prof. Dr. Huldrych Günthard » Günthard Trkola

Completed research project

Title / Titel Analysis of the correlates of protection in structured intermittent therapy: An in vivo model of acute HIV infection?
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung In this project, we will investigate humoral and innate immunity in the context of cellular immune responses in HIV-infected patients undergoing structured treatment interruptions (STI) and determine the role of these immune functions in supressing viremia. In addition we will also define virus and host genetic factors known to be important determinants of viral replication. Our objective in studying the immune response induced by STI in conjunction with virus and host pathogenic determinants is to delineate the components of the host immune system involved in clearing viremia and conferring protection. To identify these components and to determine how they are induced and regulated during STI treatment will not only improve our understanding of the HIV-1 infection but may also have implications for the development of future treatment and vaccine strategies.
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Publications / Publikationen Trkola A, Matthews J, Gordon C, Ketas T, Moore JP. A cell line-based neutralization assay for primary human immunodeficiency virus type 1 isolates that use either the CCR5 or the CXCR4 coreceptor. J. Virol. 1999; 73: 8966-8974.

Ortiz GM, Nixon DF, Trkola A, Binley J, Jin X, Bonhoeffer S, Kuebler PJ, Donahoe SM, Demoitie MA, Kakimoto WM, Ketas T, Clas B, Heymann JJ, Zhang L, Cao Y, Hurley A, Moore JP, Ho DD, Markowitz M. HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy. J. Clin. Invest 1999; 104: R13-R18.

Günthard HF, Frost S, Leigh-Brown AJ, Ignacio CC, Kee K, Spina CA, Havlir DV, Hezareh M, Looney DJ, Richman DD, Wong JK. Evolution of envelope sequences of HIV-1 in cellular reservoirs in the setting of potent antiviral therapy. 1999. Journal of Virology. 1999; 73(11):9404-9412.

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Keywords / Suchbegriffe hiv, humoral immune response, viral evolution, neutralizing antibodies, structured intermittent therapy, antiretroviral therapy, innate immunity, virus-host interaction
Project leadership and contacts /
Projektleitung und Kontakte
Huldrych Günthard, M.D. (Project Leader) huldrych.guenthard@usz.ch
A. Trkola (Project Leader) alexandra.trkola@dim.usz.ch
Funding source(s) /
Unterstützt durch
SNF (Personen- und Projektförderung)
SNF grant Nr. 3345-65168
In collaboration with /
In Zusammenarbeit mit
Prof. Sebastian Bonhoeffer
Ecology & Evolution
ETH Zurich
6336033
ETH Zentrum, NW
bonhoeffer@eco.umnw.ethz.ch
CH-8092 Zurich, Switzerland www.eco.ethz.ch
Switzerland
Prof. Rodney Phillips / Dr. Annette Oxenius
University of Oxford, Nuffield Department of Clinical Medicine
John Radcliffe Hospital
Oxford, OX3 9DU, UK
United Kingdom
Prof. Bernard Hirschel
Hopital Cantonal, Departement de medecine interne
Division des maladies infectieuses
Rue Micheli-du-Crest 24
CH-1211 Geneve
Switzerland
Duration of Project / Projektdauer Oct 2001 to Sep 2003