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Günthard

Fakultäten » Medizinische Fakultät » Infektionskrankheiten und Spitalhygiene, Klinik für » Prof. Dr. Huldrych Günthard » Günthard

Completed research project

Title / Titel Viral dynamics as a correlate of immunological response in patients treated with intermittent potent antiretroviral therapy.
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung
Intermittent antiretroviral therapy (IT) is a new therapeutic strategy. The Swiss Spanish Intermittent Therapy Trial tests, whether IT can raise immunological responses in HIV-infected patients and subsequently will lead to control of plasma viremia in the absence of antiretroviral therapy. In this substudy to the SITT we propose to perform detailed studies of viral kinetics in plasma, PBMC and lymphoid tissue for the following reasons: 1) To define virological criteria which can early predict the rise of CTL responses strong enough to control viremia in patients treated with IT. 2) To study the kinetics of viral- and immunological- (CTLs) dynamics in intermittent therapy. 3) To determine the effects of IT on lymphoid tissue and to compare results with effects of standard antiretroviral therapy on lymphoid tissue. 4) To store frequently obtained blood and tonsil tissue samples for future, potentially important studies.
In conclusion, IT is an intriguing therapeutic concept, however, bears the risk that a proportion of patients will not raise CTL, and that potency of therapy might be lost in patients successfully treated with antiretroviral therapy due to the emergence of drug resistance. If predictors detecting potent CTL responses early during IT can be developed during the first IT therapy trials, future research in this promising field will be possible because patients who will not develop CTLs could be excluded early, minimizing the risk to develop drug resistance.
Publications / Publikationen Oxenius A, Günthard HF, Hirschel B, Fidler S, Weber JN, Easterbrook PJ, Bell JI, Phillips RE, Price DA. Direct ex vivo analysis reveals distinct phenotypic patterns of HIV epitope-specific CD8+ T lymphocyte activation in response to therapeutic manipulation of virus load. Eur J Immunology 2001;31:1115-1121.
Keywords / Suchbegriffe HIV, structured intermittent therapy, antiretroviral therapy, cytotoxic T-cell response, viral kinetics, plasma viremia, lymphoid tissue, drug resistance
Project leadership and contacts /
Projektleitung und Kontakte
PD Dr. med. H. Günthard (Project Leader) huldrych.guenthard@dim.usz.ch
Funding source(s) /
Unterstützt durch
SNF (Personen- und Projektförderung)
SNF (Swiss HIV Cohort Study). (This project is a substudy to the Swiss Spanish Intermittent Therapy Trial (SSITT).
In collaboration with /
In Zusammenarbeit mit
Prof. B. Hirschel, University Hospital Geneva, Geneva Switzerland
Dr. A. Oxenius, Prof. R. Phillips, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford United Kingdom
Prof. A. McLean, University of Oxford, Oxford United Kingdom
Duration of Project / Projektdauer Jul 1999 to Jul 2002