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Kometer Vollenweider

Fakultäten » Medizinische Fakultät » Psychiatrische Universitätsklinik » Psychiatrie, Psychotherapie und Psychosomatik, Klinik für » Prof. Dr. F. X. Vollenweider » Kometer Vollenweider

Completed research project

Title / Titel Neurophysiological signatures of serotonergic manipulations on verbal self-monitoring, self-experience and self-other dynamics
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung Processing of speech is a complex phenomenon unfolding in time. The high temporal resolution of the event-related potentials (ERPs) embedded in the EEG signal is particularly well suited for tracing the brain responses to acoustic and linguistic properties of speech. Signal polarity, amplitude and topographic scalp distribution provide an objective index of brain activity reflecting different aspects of information processing, from earlier sensory to later cognitive stages. The N100 has been particularly linked to an early abstraction and percept formation, detection of speech degradation, and scanning of auditory short-term memory. The present study aims at investigating the effects of serotonergic manipulations by psilocybin in healthy humans on speech production in a self-monitoring task with stimuli varying in source and pitch, through comparison with placebo at three different analysis levels: behavioral, neuronal and experiential. The behavioral level includes recognition and misattribution, the neuronal level containes the cortical EEG response to self- and other-referential stimuli and underlying neural generators, the experiential level includes the self-report assessment of drug-induced alterations in self-related perceptions. A better understanding of the neural mechanisms of self monitoring is crucial for the development of novel treatment approaches to dysfunctional self-referential processing in psychiatric disorders.
Project leadership and contacts /
Projektleitung und Kontakte
Dr. Michael Kometer (Project Leader) michael.kometer@bli.uzh.ch
Prof.Dr. Franz Vollenweider (Project Leader) vollen@bli.uzh.ch
MSc Lukasz Smigielski Lukasz.Smigielski@bli.uzh.ch
Funding source(s) /
Unterstützt durch
Foundation
 
In collaboration with /
In Zusammenarbeit mit
Dr. Thomas Koenig, Department of Psychiatric Neurophysiology, University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, CH-3000 Bern, Switzerland Switzerland
Duration of Project / Projektdauer Jan 2014 to May 2016