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Kometer Vollenweider

Fakultäten » Medizinische Fakultät » Psychiatrische Universitätsklinik » Psychiatrie, Psychotherapie und Psychosomatik, Klinik für » Prof. Dr. F. X. Vollenweider » Kometer Vollenweider

Completed research project

Title / Titel NMDA-Receptor dependent theta oscillations for coding the expected and actual feedback value in reinforcement learning
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung Reinforcement learning is an adaptive process allowing humans to improve the outcome of future choices based on the consequences of previous choices. While dopamine is crucial for this adaptive mechanism, recent animal studies support an additional contribution of NMDA receptors. A disruption in reinforcement learning as well as NMDA receptor activity was found in psychiatric disorders such as schizophrenia. Therefore, we here address the idea that altered NMDA receptor activity disrupts the neuronal mechanisms underlying reinforcement learning, leading in the formation of cognitive impairments such as thought disorders. To elucidate this idea healthy human subjects received in a randomized, double-blind study on three separate days placebo, and a low-dose and a high-dose of the NMDA antagonist ketamine. Subjects conducted a probabilistic learning during high-density EEG recording.
Project leadership and contacts /
Projektleitung und Kontakte
Dr. Michael Kometer (Project Leader) michael.kometer@bli.uzh.ch
Prof. Franz Vollenweider (Project Leader) vollen@bli.uzh.ch
Funding source(s) /
Unterstützt durch
Foundation
 
In collaboration with /
In Zusammenarbeit mit
Dr. Erich Studerus, Dept. of Psychiatry, University of Basel Switzerland
Duration of Project / Projektdauer Jul 2014 to May 2016