Schwarzwald Feige

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Completed research project

Title / Titel	Comparison of low-molecular-weight heparin and unfractioned heparin for prophylaxis of coagulation disorders in horses
PDF	Abstract (PDF, 14 KB)
Original title / Originaltitel	Vergleich von niedermolekularem und unfraktioniertem Heparin zur Prophylaxe von Gerinnungsstörungen beim Pferd
Summary / Zusammenfassung	Heparin is used for treatment of coagulation disorders associated with severe gastrointestinal disease, septicemia and endotoxemia in horses. Further indications are the prevention of laminitis, intraabdominal adhesions, disseminated intravascular coagulation, venous thrombosis and thrombophlebitis. Unfractioned heparin (UFH) has some undesirable side effects. In horses, a rapid decrease in packed cell volume (PCV), erythrocyte agglutination, thrombocytopenia and hemorrhage are frequently associated with use of unfractioned heparin. Furthermore, unfractioned heparin has unpredictable pharmakokinetic properties and there is marked individual variation of sensitivity to heparin in horses and human beings. Low-molecular-weight heparin (LMWH) is routinely used in human medicine. LMWH has reduced side effects, higher bioavailability, longer half-inactivation time and dose-dependent anticoagulatory effect. However, LMWH has similiar antithrombotic properties as UFH. The purpose of the study is to compare the action and side effects of unfractioned and low-molecular-weigt heparin for prophylaxis of coagulation disorders in gastrointestinal disease in horses.
Publications / Publikationen	Dissertation C. Schwarzwald (in Bearbeitung)
Keywords / Suchbegriffe	Pferd, Kolik, Gerinnungsstörungen, Heparin, Niedermolekulares Heparin, Unfraktioniertes Heparin, Arzneimittel, Dissertation, horse, colic, coagulation disorders, heparin, low-molecular-weight heparin, unfracioned heparin, drugs
Project leadership and contacts / Projektleitung und Kontakte	med. vet. C. Schwarzwald (Project Leader) schwarzw@vetklinik.uzh.ch Dr. med. vet. Karsten Feige (Project Leader) kfeige@vetklinik.uzh.ch Prof. Dr. med. vet. Ueli Braun ubraun@vetklinik.uzh.ch
In collaboration with / In Zusammenarbeit mit	Dr. Th. Bombeli Department of Internal Medicine Hematology University of Zurich, Switzerland. Switzerland
Duration of Project / Projektdauer	Jul 1998 to May 2001