Fakultäten » Medizinische Fakultät » Konsiliarpsychiatrie und Psychosomatik, Klinik für » Prof. Dr. Gabriella Milos » milos

Completed research project

Title / Titel „Reshaping“ the Brain – Longitudinal Assessment of Changes in Functional and Structural Connectivity During Weight Gain in Anorexia Nervosa
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung Aim
To map and understand plastic processes of recovery in anorexia nervosa through a multiple-level approach.

Acute anorexia nervosa (AN) is characterized by strong emotional involvement and brain atrophy. It is still not understood in which regions and to what extent these atrophic processes are reversible. Connectivity, i.e. the dynamic interplay of remote brain regions, constitutes the basic neural processes and plays a role in all plastic processes. However, connectivity has received little attention in AN so far. In particular, the relations between functional and structural connectivity in a longitudinal design, as well as the influence of connectivity changes on grey matter increase, need investigation to gain a better understanding for the “reshaping” of the brain in AN during therapy.

Magnetic resonance imaging (MRI) is performed to obtain measures of brain activity (functional aspect) and brain morphology/white matter organization (structural aspect). Forty patients with acute AN undergo MRI at three distinct time points, defined by respective current body-mass index, during a multi-modal interdisciplinary therapy in the stationary setting of the Centre of Eating Disorders, University Hospital Zurich. Data are compared with 20 healthy women as well as with 20 recovered AN subjects. Resting-state functional connectivity, structural connectivity in white matter, and volumes/thickness in grey matter will be interlinked. Given the sought changes in emotional attitude towards body and food during therapy, target regions relate to the salience and reward networks (anterior insula, amygdala, nucleus accumbens, anterior cingulate and orbitofrontal cortex) which are most likely to be involved in plastic processes in AN.
Keywords / Suchbegriffe anorexia nervosa, structural connectivity, functional connectivity, weight gain
Project leadership and contacts /
Projektleitung und Kontakte
prof dr gabriella milos (Project Leader)
dr volker baur
prof dr lutz jäncke Lutz Jäncke
prof dr spyros kollias
prof dr ulrich schnyder
prof. dr chantal martin soelch
Funding source(s) /
Unterstützt durch
In collaboration with /
In Zusammenarbeit mit
Prof. Dr. med. Gabriella Milos, Leitende Ärztin
Zentrum für Essstörungen, Klinik für Psychiatrie und Psychotherapie
UniversitätsSpital Zürich
Culmannstr. 8
8091 Zürich

Tel.: +41 44 255 52 80
Fax: +41 44 255 45 30
Duration of Project / Projektdauer Oct 2013 to Oct 2016