Fakultäten » Medizinische Fakultät » Infektionskrankheiten und Spitalhygiene, Klinik für » Prof. Dr. Huldrych Günthard » Günthard

Completed research project

Title / Titel Swiss HIV Cohort Study (SHCS)
PDF Abstract (PDF, 14 KB)
Original title / Originaltitel Schweizerische HIV Kohortenstudie
Summary / Zusammenfassung The SHCS is a fully established cohort that was started in 1988. Since then, ~19000 patients were enrolled and in 2013, almost 9000 were followed actively. From the beginning, the SHCS was an open, longitudinal cohort, enrolling continuously individuals from all transmission groups. In 2003 the “Swiss Mother and Child HIV Cohort Study” (MoCHiV) was integrated into the SHCS. Early on, the SHCS unified clinical, translational, basic, social and epidemiological science, as well more recently also nursing research. The considerable scientific impact of the SHCS and MoCHiV is illustrated by more than 700 publications in peer reviewed journals that directly emerged from these studies, respectively were made possible by significant contributions of the SHCS. One of the hallmarks of the SHCS is that this research network was able to rapidly respond to new scientific findings and challenges in the field. The SHCS is nationwide highly representative. At least 45% of all HIV-infected individuals living in Switzerland, 75% of all patients with AIDS and 75% of all patients on antiretroviral treatment participate in the SHCS. The SHCS has a strong impact on public health in Switzerland and includes: (i) Providing high quality data on HIV transmission, (ii) preventing HIV-transmission by optimal treatment and counseling, (iii) informing care givers on optimal screening and treatment interventions, (iv) providing key data on how to prevent and treat opportunistic infections, (v) monitoring co-infections and other sexually transmitted infections (STI), (vi) providing behavioral data on sexual activities, on prevention measures, substance abuse, depression prevalence, employment status, and activities of daily living, (vii) performing cost effectiveness studies with regard to diagnostic procedures, (viii) monitoring transmission of HIV drug resistance, (ix) continuously delivering high quality data for prevention campaigns, (x) providing feedback to physicians on treatment outcome and mortality compared to other settings.
Weitere Informationen
Publications / Publikationen Weitere Informationen
Keywords / Suchbegriffe Swiss HIV Cohort Study, HIV, immune deficiency, CD4 cells, viral load, antiretroviral treatment, drug resistance, evolution, immune response, hiv epidemic, virus host interaction, toxicity, side effects, GWAS, phylogeny, HIV/HCV co-infection, HIV/HBV co-infection, HIV transmission, mother to child transmission, pregnancy, drug resistance database, opportunistic infections,
Project leadership and contacts /
Projektleitung und Kontakte
Professor Huldrych Günthard, guenh (Project Leader)
Other links to external web pages
Funding source(s) /
Unterstützt durch
SNF (Programm NFP), Foundation, Private Sector (e.g. Industry)
Cohort Studies
In collaboration with /
In Zusammenarbeit mit
Weber, Rainer, USZ, UZH
Vernazza, Pietro Luigi, Kantonsspital St. Gallen,
Kaiser, Laurent, HUG
Telenti, Amalio, UNIL
Cavassini, Matthias, CHUV
Burton-Jeangros, Claudine; HUG
Barth, Jürgen, UBE
Nadal, David ; KISPI
Bernasconi, Enos, Hospidale Civico Lugano
Tarr, Philip Eduard, Kantonsspital Bruderholz, Basel
Martinez de Tejada Weber, Begoña, HUG
Klimkait, Thomas, UBA
Battegay, Manuel, UBA
Hösli, Irene, UBA
Fellay, Jacques, EPFL; CHUV
Furrer, Hansjakob, Inselspital, UBE
Bucher, Heiner C., UBA
Egger, Matthias, UBE
Rauch, Andri, Inselspital, UBE
Calmy, Alexandra, HUG
Ledergerber, Bruno, USZ, UZH
Metzner, Karin, USZ, UZH
Duration of Project / Projektdauer Jan 2014 to Dec 2015