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Günthard

Fakultäten » Medizinische Fakultät » Infektionskrankheiten und Spitalhygiene, Klinik für » Prof. Dr. Huldrych Günthard » Günthard

Completed research project

Title / Titel Clinical presentation and unusual features of 290 patients with an acute HIV-1 infection and evaluation of an acute HIV-1 infection severity score to determine the clinical, virological and immunological outcome.
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung The early phase of HIV-1 infection is of critical pathogenetic and clinical significance. Viral and host-specific properties are of crucial importance for the later course of the HIV-1 infection. Diagnosing primary infection requires a high index of suspicion, recognition of the clinical manifestations, as well as knowledge of the diagnostic tools required in order to identify those who test negative by antibody-based diagnostic tools. Although the clinical manifestations of primary infection are highly varying and because they are unspecific and often missed, there has been considerable interest in defining signs or symptoms that might assist in targeting the use of specialized diagnostic tests, as well as the relationship with acceleration in the natural history of disease. The original descriptions of primary HIV-1 infection characterized it as a ‘mononucleosis-like’ illness at a time when the patient is viremic but without HIV-1 antibodies. However, early reports described cohorts with selected clinical and laboratory abnormalities. During our ongoing study-period we collected comprehensive data about common and unusual features of PHI from 290 patients. Based on our PHI-database we want now to identify in a systematic manner the different clinical and laboratory presentations with attention to unusual features and severe illnesses. To our knowledge, there exists no published data using a PHI severity illness score (PHISIS) and worldwide there are not many studies that are capable to generate one. We therefore intend to create and evaluate a PHISIS which helps to determine the clinical, virological and immunological outcome of patients with PHI. The creation of a numerically available clinical phenotype will allow us to investigate virus-host interactions in regard to clinical presentation of the disease. All patients are virologically typed and comprehensive host genotyping by whole exome chip technology including rare genetic variants is ongoing. Thus, careful analysis of clinical presentation in conjunction with these data will help to better connect clinical presentation to virus and host genetic features.
Keywords / Suchbegriffe Zurich Primary HIV Infection, acute retroviral syndrome, CD4, viral load, clinical score, acute hiv infection
Project leadership and contacts /
Projektleitung und Kontakte
Prof. Huldrych Günthard, MD (Project Leader) huldrych.guenthard@usz.ch
Dr. Dominique Braun, MD dominique.braun@usz.ch
Funding source(s) /
Unterstützt durch
Others
University Hospital Zurich, Matching Funds
In collaboration with /
In Zusammenarbeit mit
Dr. Roger Kouyos, Div. Infect. Diseases, University Hospital Zurich Switzerland
Duration of Project / Projektdauer Nov 2012 to Dec 2013