Wüthrich

Fakultäten » Medizinische Fakultät » Nephrologie, Klinik für » Prof. Dr. Rudolf Wüthrich » Wüthrich

Current research project

Title / Titel	POSTOP (Prolia for Osteoporosis of Transplant Operated Patients): A phase 3, investigator-initiated, randomized, open-label single-center study of the effect of denosumab on the prevention of bone mineral density loss after renal transplantation
PDF	Abstract (PDF, 14 KB)
Original title / Originaltitel	Denosumab zur Prävention der Knochendichteverminderung nach Nierentransplantation
Summary / Zusammenfassung	Osteoporotic fractures represent a major problem after solid organ transplantation. Due to their nephrotoxic potential bisphosphonates have not been widely used in these patients. The purpose of the present study is to test in a randomized clinical trial whether the new anti-osteoporotic drug denosumab (Prolia®) has a beneficial effect on the loss of bone mineral density (BMD) in the first year after renal transplantation (primary endpoint). One hundred newly transplanted renal allograft recipients will be randomized 1:1 to receive either denosumab 60 mg s.c. every 6 month or no therapy. Changes in body height and bone mineral metabolism parameters, incidence of fractures, and allograft function at 1 year will also be assessed. Safety measurements include the occurrence of rejection episodes, graft loss and mortality. This investigator-initiated study will conclusively demonstrate whether denosumab treatment is beneficial in renal transplant recipients. Weitere Informationen
Project leadership and contacts / Projektleitung und Kontakte	Prof. Rudolf Wüthrich, MD (Project Leader) rudolf.wuethrich@usz.ch
Funding source(s) / Unterstützt durch	Others ZKF matching fund
In collaboration with / In Zusammenarbeit mit	Dr. Diana Frey Klinik für Rheumatologie Universitätsspital Rämistrasse100 8091 Zürich Email: diana.frey@usz.ch Switzerland
Duration of Project / Projektdauer	Jun 2011 to Dec 2014