|Title / Titel||Structure and safety of hallucinogen-induced ASC|
|Abstract (PDF, 14 KB)|
|Summary / Zusammenfassung||The OAV questionnaire has been developed to integrate research on altered states of consciousness (ASC). It measures three primary and one secondary dimensions of ASC that are hypothesized to be invariant across ASC induction methods. The OAV rating scale has been in use for more than 20 years and applied internationally in a broad range of research fields, yet its factorial structure has never been tested by structural equation modeling techniques and its psychometric properties have never been examined in large samples of experimentally induced ASC.
The present study will conducte a psychometric evaluation of the OAV in a sample of
psilocybin (n = 327), ketamine (n = 162), and MDMA (n = 102) induced ASC that was obtained by pooling data from 43 experimental studies of our laboratory. The factorial structure will be examined by confirmatory factor analysis, exploratory structural equation modeling, hierarchical item clustering (ICLUST), and multiple indicators multiple causes (MIMIC) modeling. The study also aims at investigating the acute and subacute effects and safety of psilocybin-induced states as well as to delineate potential predictors of outcome of hallucinogen-induced states in general in healthy humans.
|Publications / Publikationen||Studerus E, Gamma A, Vollenweider FX (2010) Psychometric Evaluation of the Altered States of Consciousness Rating Scale (OAV). PLoS ONE 5(8):
e12412. doi:10.1371/journal.pone.0012412Studerus E, Kometer M, Hsler F, Vollenweider FX (2010) Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies. Journal of Psychopharmacology, ahead of print, DOI: 10.1177/0269881110382466Studerus, E., Gamma, A., Kometer, M., Vollenweider, F.X. (2011) Prediction of psilocybin response in healthy volunteers, PLoS ONE(in press)
|Keywords / Suchbegriffe||altered states of consciousness, hallucinogens, psychology, structural equation modeling, predictors, safety, metaanalysis|
|Project leadership and contacts /
Projektleitung und Kontakte
|Funding source(s) /
|Duration of Project / Projektdauer||Nov 2008 to Sep 2011|