|Title / Titel||Adherence as a predictor of the development of class-specific resistance mutations|
|Abstract (PDF, 14 KB)|
|Summary / Zusammenfassung||2.1. Antiretroviral therapy aims at continuous and lasting suppression of viral replication, which is one of the most important factors influencing long-term prognosis of HIV-infected individuals. Non-adherence to therapy has been shown to be one of the strongest predictors of therapeutic failure of antiretroviral therapy. Virologic failure with concurrent respectively subsequent emergence of resistance reduced future treatment options and therefore long-term clinical success of anti HIV treatment. Drug-resistant strains of HIV can then be transmitted to uninfected or drug-naïve individuals limiting their future treatment options already from the very beginning of the infection, making this an important public-health topic.
2.2 Study Aims
The goal of the study is to estimate the impact of adherence to ART on the development of class-specific resistance mutations in patients starting a new class of ART.
2.3 Study Design
Prospective observational cohort study including patients who start a new class of ART regimen for which they are naïve between January 1, 2003 and January 1, 2010. Participants must complete at least one adherence questionnaire prior to resistance testing performed upon treatment failure. The primary definition of non-adherence will be defined as the self-reported number of missed doses (0, 1, 2, or >2) in the past 4 weeks. The primary outcome is the development of class-specific drug resistant mutations. Logistic regression models will be used to estimate the effect of adherence to ART on resistance for each class of ART.
|Project leadership and contacts /
Projektleitung und Kontakte
|Funding source(s) /
|SNF (Personen- und Projektförderung)
Swiss HIV Cohort Study
|Duration of Project / Projektdauer||Dec 2010 to Dec 2012|