Boehler Russi Speich
Fakultäten » Medizinische Fakultät » Pneumologie, Klinik für » Prof. Dr. Erich Russi » Boehler Russi Speich
Completed research project
| Title / Titel | Posttransplant bronchiolitis obliterans and characterization of potential inhibitory mechanisms | ||||||
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| Abstract (PDF, 14 KB) | |||||||
| Summary / Zusammenfassung | Posttransplant bronchiolitis obliterans, considered to be a form of chronic allograft rejection, is the major obstacle to longterm survival of lung transplant recipients to date. Using a heterotopic rodent airway transplant model we have characterized dif | ||||||
| Publications / Publikationen | A.Boehler, D.Chamberlain, S.Kesten, A.Slutsky, M.Liu, S.Keshavjee: Lymphocytic airway infiltration as a precursor to fibrous obliteration in a rat model for bronchiolitis obliterans, Transplantation 1997;64(2):311-317.A.Boehler, X.H.Bai, M.Liu, S.Cassivi, D.Chamberlain, A.S.Slutsky, S.Keshavjee: Persistent upregulation of Th1-type cytokines and differential expression of C-C and C-X-C chemokines in post-transplant airway obliteration., Am J Resp Crit Care Med 1999 (in press).A.Boehler, D.Chamberlain, Z.Xing, A.S.Slutsky, M.Jordana, J.Gauldie, M.Liu, S.Keshavjee: Adenoviral-mediated IL-10 gene transfer inhibits post-transplant fibrous airway obliteration in an animal model of bronchiolitis obliterans. Hum Gene Therapy, Hum Gene Therapy 1998;9(4):541-551. | ||||||
| Keywords / Suchbegriffe | Transplantation Medicine, Immunology | ||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
SNF (Personen- und Projektförderung), Others |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Jun 1998 to Jun 2000 |