Fakultäten » Medizinische Fakultät » Infektionskrankheiten und Spitalhygiene, Klinik für » Prof. Dr. Huldrych Günthard » Günthard

Completed research project

Title / Titel Raltegravir Use in the SHCS– Evaluation of Efficacy, Safety, Plasma Levels and Evolution of Resistance
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung Since June 2007, raltegravir has been available in Switzerland within a named patient program for patients who have virologic failure, triple class experience and resistance, and no other treatment options. This proposal has been designed to evaluate efficacy and safety data among patients who receive raltegravir within the routine clinical practice in Switzerland and who participate in the SHCS. This is a combined retrospective analysis of patients who already received raltegravir and a prospective part of patients who enter the named patient program and will be followed up in a standardized way. In the prospective part, patients will also be able to receive raltegravir in case of intolerance to their current medication with virologic suppression.
The analysis will primarily use descriptive statistics. In addition, we will assess the duration of virologic response and focus on predictors of HIV RNA suppression during a follow-up of at least 6 months. In the prospective part, we will assess trough plasma levels of raltegravir and other antiretrovirals. In patients who will develop virologic failure, genotypic and phenotypic resistance to raltegravir (and other antiretrovirals) will be performed to characterize the evolution of resistance during the raltegravir-containing regimen.
Keywords / Suchbegriffe HIV, antiretroviral treatment, integrase inhibitor
Project leadership and contacts /
Projektleitung und Kontakte
Prof. Huldrych Günthard, M.D. (Project Leader)
Funding source(s) /
Unterstützt durch
SNF (Personen- und Projektförderung), Private Sector (e.g. Industry)
The Study is financed by the Swiss HIV Cohort Study and a unrestricted research grant from Merck Sharp and Dohme, Zurich, Switzerland
In collaboration with /
In Zusammenarbeit mit
All study centers and study sites of the Swiss HIV Cohort Study Switzerland
Duration of Project / Projektdauer Sep 2008 to Aug 2010