Straumann
Fakultäten » Medizinische Fakultät » Neurologie, Klinik für » Prof. Dr. Dominik Straumann » Straumann
Completed research project
| Title / Titel | Three-dimensional kinematical analysis of ocular motor disorders in humans | ||||||
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| Abstract (PDF, 14 KB) | |||||||
| Summary / Zusammenfassung | The long-term goal of this research (since 1998) is to better understand diseases of the ocular motor system in humans and to assess potential treatments. The focus of interest is on the three-dimensional (horizontal, vertical, torsional) kinematical properties of ocular rotations. Specifically, we explore eye movements in patients with peripheral vestibular lesions, cerebellar disorders, and strabismus as well as in healthy human subjects. We now extend our experimental work to the linear vestibulo-ocular reflex (LVOR) and concentrate on the orienting (i.e. tilt) LVOR in the roll (AIMS 1&2) and pitch (AIM 3) planes and how it is affected by peripheral (e.g. vestibular neuritis) or central (e.g. atrophy of the vestibulo-cerebellum) disorders. Our first major hypothesis is that the orienting LVOR in the roll plane represents an ocular response to interaural acceleration, irrespective of whether the gravito-inertial force vector (GIFV) is changing its direction relative to the head (i.e. tilt) or changing its magnitude (i.e. acceleration along the gravity vector). Such a LVOR would be merely pseudo-orienting, because ocular roll has no orienting purpose during accelerations along the gravity vector (AIM 1). - Our second major hypothesis is that otolith-driven ocular roll not only has a conjugate component in response to head roll or interaural acceleration (y-axis) but also a disconjugate component in response to longitudinal acceleration (z-axis). We conjecture that these two components represent different otolith-ocular reflexes that use separate pathways and hence can be differentially affected by one-sided peripheral-vestibular lesions (AIM 2). – Finally, we hypothesize that the vestibulo-cerebellum normally inhibits the orienting (i.e. tilt) VOR in the pitch plane. Specifically, we wish to further explore whether the gravity dependence of cerebellar downbeat nystagmus represents an overacting otolith-ocular reflex (AIM 3). This research uses the latest techniques for vestibular stimulation (hexapod motion simulator, motorized multi-axes turntable) and eye-head movement recordings (dual search coil technique). | ||||||
| Publications / Publikationen | Weber KP, Landau K, Palla A, Haslwanter T, Straumann D (2004) Ocular rotation axes during dynamic Bielschowsky head-tilt testing in unilateral trochlear nerve palsy. Invest Ophthalmol Vis Sci 45: 455-65 Helmchen C, Sprenger A, Rambold H, Sander T, Kömpf D, Straumann D (2004) Effect of 3,4-diaminopyridine on the gravity dependence of ocular drift in downbeat nystagmus. Neurology 63: 752-753 Schmid-Priscoveanu A, Kori AA, Straumann D (2004) Torsional vestibulo-ocular reflex during whole-body oscillation in the upright and the supine position: II. Responses in patients after vestibular neuritis. J Vest Res, 14: 353-359 Palla A, Straumann D (2004) Recovery of the high-acceleration vestibulo-ocular reflex after vestibular neuritis. J Ass Res Otolaryngol 5: 427-435 Palla A, Marti S, Straumann D (2005) Head-shaking nystagmus depends on gravity. J Ass Res Otolaryngol 6: 1-8 Marti S, Bockisch CJ, Straumann D (2005) Prolonged asymmetric smooth pursuit stimulation leads to downbeat nystagmus in healthy human subjects. Invest Ophthalmol Vis Sci 46: 143-149 Palla A, Bockisch CJ, Bergamin O, Straumann D (2006) Dissociated hysteresis of static ocular counterroll in humans. J Neurophysiol 95 : 2222-2232 Marti S, Bockisch CJ, Straumann Dominik (2006) Asymmetric and symmetric and short-term adaptation of the vertical VOR in humans. Exp Brain Res: 172: 343-350 Jorns-Häderli M, Straumann D, Palla A (2007) Accuracy of the bedside head-impulse test in detecting vestibular hypofunction. J Neurol Neurosurg Psychiatry 78: 1113-1118 Palla A, Hegemann S, Widmer U, Straumann D (2007) Vestibular and auditory deficits in Fabry disease and their response to enzyme replacement therapy. J Neurol 254: 1433-1442Weitere Informationen |
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| Keywords / Suchbegriffe | eye movement disorders; vestibular disorders; humans; neuroophthalmology;, neuro-otology; neurology; three-dimensional ocular kinematics;, otoliths; gravity; vestibulo-ocular reflex; rotation; translation;, adaptation; compensation | ||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Other links to external web pages | http://www.vertigocenter.ch/straumann | ||||||
| Funding source(s) / Unterstützt durch |
SNF (Personen- und Projektförderung) Betty and David Koetser Foundation for Brain Research |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Oct 2007 to Sep 2010 |