Snedeker
Fakultäten » Medizinische Fakultät » Universitätsklinik Balgrist und Schweizerisches Paraplegikerzentrum » Orthopädie » Prof. Dr. Jess Snedeker » Snedeker
Completed research project
| Title / Titel | Gradient matrices for directing stem cell differentiation. | ||
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| Abstract (PDF, 14 KB) | |||
| Summary / Zusammenfassung | An enormous challenge in medical stem cell research is to learn how to direct differentiation toward specific cell fates. We hypothesize that mesenchymal stem cell (MSC) differentiation in vivo reflects the local mechanical environment of the cell, and can be controlled by engineering the mechanical properties of the cell substrate. Human MSCs will be seeded and cultured on micro-engineered gel substrates with stiffness optimized for cell differentiation into bone, tendon, and muscle. The forces between cell and matrix will be measured, and the cellular stress state associated with lineage specification will be explored to understand the role of forces in regulating stem cell biology - with the concrete clinical aim of improving tissue engineered orthopaedic implants. | ||
| Keywords / Suchbegriffe | Tissue Engineering, Stem Cells, Cell Mechanics, Biomechanics | ||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Other links to external web pages | http://www.biomechanics.ch | ||
| Funding source(s) / Unterstützt durch |
Foundation Bonizzi-Theler Stiftung |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Sep 2007 to Dec 2009 |