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Prof. Dr. Huldrych Günthard

Fakultäten » Medizinische Fakultät » Infektionskrankheiten und Spitalhygiene, Klinik für » Prof. Dr. Huldrych Günthard

Current research projects

Project leader Project title
Beerenwinkel Günthard Large-scale statistical analysis of treatment change episodes in the SHCS database
Beerenwinkel Günthard Metzner Ultra-deep sequencing of HIV: a pilot study evaluating the benefit for predicting therapy outcome
Fellay Viral genotype as study phenotype in human genome-wide association analysis
Fischer Günthard Identification of mechanisms controlling HIV-latency in vivo and targets to clear the latent reservoir of HIV-1
Glass Von Wyl Adherence as a predictor of the development of class-specific resistance mutations
Günthard Long-term trends and transmission of individual drug resistance mutations as defined by the IAS-USA mutation list in the Swiss HIV cohort Study and dependence on changing antiretroviral treatment regimens
Retrospective Sequencing of old sequences for complementation of the Swiss HIV Cohort Drug Resistance Database
Characterization of acute and recent HIV-1 infections in Zurich: a long-term observational study
HIV-Transmission in Switzerland: Long term-molecular epidemiology and biological properties of transmitted viruses
Günthard Metzner Prevalence and relevance of HCV drug resistance in the SHCS
Minority quasispecies of drug-resistant HIV-1: Emergence, transmission, dynamics, and clinical relevance in acute and chronic HIV-1 infection.
Clinical impact of minority quasispecies of drug-resistant HIV-1 on first-line treatment containing a NNRTI in treatment-naïve, chronically HIV-1 infected patients
HIV-1 whole-genome quasispecies analysis by ultra-deep sequencing and computational haplotype inference to determine the mechanisms of drug resistance development
Evolution and diversity of Human Immunodeficiency Virus 1 in vivo
Hangartner Günthard Isolation and characterization of heterosubtypic influenza virus-specific antibodies
Oxenius Günthard Humoral immune response to gastrointestinal bacteria as a potential read-out for microbial translocation during late-stage HIV-1 infection
Pillay Günthard Collaborative HIV and Anti-HIV Drug Resistance Network - CHAIN
Rauch Metzner Günthard Prevalence and relevance of HCV drug resistance in the SHCS
von Wyl Günthard Using viral sequence data to inform the parametrization of mathematical models of theHIV-1 epidemic in Switzerland

Completed research projects

Project leader Project title
Alizon Günthard Bonhoeffer Measuring the heritability of set-point viral load in HIV-1 infections
Bonhoeffer Günthard The rate paradox in HIV evolution: Resolving the discrepancy between the within and between patients rates of evolution of HIV-1
Günthard Viral dynamics as a correlate of immunological response in patients treated with intermittent potent antiretroviral therapy.
Humoral immunity to HIV-1: Analysis of the function of antibody responses as correlate and surrogate marker of viremia control
HIV-1 drug resistance in the Swiss HIV Cohort Study: Epidemiology and impact on the management of HIV infected patients
Factors associated with viral control after primary HIV-1 infection and viral determinants associated with HIV-1 transmission
Evaluation of possible impact of minor populations of 3TC-resistant mutations in the reverse transcriptase of HIV-1 in acute seroconverters on the effect of antiretroviral therapy.
Completing the Swiss HIV-Cohort drug resistance database: A comprehensive, longitudinal, representative tool to address resistance at at the level of basic, epidemiological and clinical science.
Estimate of potential antiretroviral activity of Etravirine in the SHCS based on genotypic drug resistance information.
Swiss HIV Cohort Study: “Evaluation of potential underdetection of plasma HIV RNA in patients of the SHCS by the Roche Taqman assay when compared to the Roche Amplicor monitor assay
Raltegravir Use in the SHCS– Evaluation of Efficacy, Safety, Plasma Levels and Evolution of Resistance
Estimate of potential antiviral activity of Etravirine in the SHCS based on genotypic drug resistance information.
ZIEL Study: "Zurich HIV Genotyping and Drug Level - Study."
Primary HIV-1 infection in Zurich
Linking the SmartGene and SHCS databases for developing a useful research tool
Evolution of the V3-loop of HIV-1 envelope from plasma of patients undergoing structured treatment interruptions
A probe study to evaluate HIV-1 specific cell mediated immune responses in HIV-1 infected patients treated with potent antiretroviral therapy (ART) during acute or recent infection (Product V520, Protocol 013-01)
Günthard Trkola Analysis of the correlates of protection in structured intermittent therapy: An in vivo model of acute HIV infection?
Müller Günthard Ethnic differences in the progression of untreated HIV infections in the SHCS
Pillay Günthard Antiviral role of APOBEC3 in HIV/HCV coinfected patients: survey of peginterferon-treated individuals in the SHCS