Prof. Dr. Gerd Kullak-Ublickmore information

Fakultäten » Medizinische Fakultät » Klinische Pharmakologie und Toxikologie, Klinik für » Prof. Dr. Gerd Kullak-Ublick

Current research projects

Project leader	Project title
Jetter	Dose-effect relationship between allopurinol, azathioprine and 6-thioguanine nucleotide levels (6-TGN) in inflammatory bowel disease patients.
Kullak-Ublick	NCCR-Kidney.CH: Control of nutrient and drug bioavailability by the kidney: impact of uninephrectomy on drug and bile acid transport
Kullak-Ublick Eloranta	ProDoc: Regulation of genes encoding metabolizing enzymes and drug transporters by xenobiotic- and oxidative stress-responsive transcription factors
Stieger	The Role of Microdomains in Canalicular Bile Formation
	ProDoc: Role of skeletal muscle transport systems in statin-induced myotoxicity
	NCCR Transcure: Role of canalicular lipid secretion in acquired forms of cholestasis

Completed research projects

Project leader	Project title
Eloranta	Regulation of genes encoding drug transporters of the SLC family by xenobiotic and oxidative stress-responsive transcription factors in the liver, intestinal, and kidney cells
Fattinger	Pharmacokinetics of Diacetylmorphine in Narcotic Addicts
Hagenbuch	Molecular physiology of bile acid, organic anion and drug transport within the enterohepatic circulation
	Physiological and molecular characterization of multispecific organic anion transporting polypetides
Jetter	Genetic influences on the inducibility of cytochrome P450 enzymes.
Kullak-Ublick	Drug and organic anion transport by human liver: pharmacological characterization, analysis of expression and genetic regulation of hepatocellular organic anion transporting proteins (OATPs)
	Functional characterization and transcriptional regulation of drug and bile acid transporters in human liver and intestine
	Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS)
	Regulation and genetic variability of drug and organic anion transporter genes: implications for liver and intestinal diseases
	Regulation and functional characterization of transporters for drugs and endogenous substances in the human intestine
	Barrett's Esophagus: role of transcription factors CDX1 and CDX2 in diagnosis and molecular pathogenesis
	Molecular and Functional characterization and Regulation of Expression of Drug and Organic Anion Uptake Systems in Human Liver
Meier-Abt	Molecular Physiology and Pathophysiology of Hepatic Bile Formation and Cholestatic Liver Disease
	Mechanisms of Canalicular Bile Salt and Cholesterol Secretion
Meier-Abt Fattinger	Drug Safety in Inpatients / Comprehensive Hospital Drug Monitoring CHDM: Pharmacoepidemiologic Research Database on Medical Inpatients
Pauli Magnus	Effect of Ritonavir on the Pharmacokinetics of the Benzimidazoles Albendazole and Mebendazole
St-Pierre	The identification of transporters involved in steroidogenesis in the materno-fetal-placental unit.
Stieger	Optimization and pre-validation of an in vitro test strategy of predicting human acute toxicity. EU contract no.: FP6-512051 WP 7.3: Hepatotoxicity, partner no. 28
	Molecular physiology of bile formation: acute regulation of canalicular bile salt and organic anion secretion and relation to canalicular lipid secretion
Stieger Meier-Abt	Hepatocyte Transplantation for End Stage Liver Disease: Potential of Hepatocyte Progenitor Cells and Bone Marrow Stem Cells
Vavricka	Role of bacteria-derived peptides in intestinal epithelial cells in health and in patients with inflammatory bowel disease