| Project leader |
Project title |
| Ferrari |
Regulation of human Exonuclease 1 by Ubiquitinylation |
|
Regulation of DNA mismatch repair by phosphorylation: a cell division cycle perspective |
|
Mechanism of resistance of Aurora-A overexpressing tumors to chemotherapy |
|
Regulation of Human Exonuclease 1 by Phosphorylation and Protein-Protein Interactions: Implications in DNA Synthesis and Repair |
|
Regulation of human Exonuclease 1 by Ubiquitylation |
|
Mechanism of resistance of AURORA-A over-expressing tumors to chemotherapy |
|
Identification of novel pathways controlled by the oncogene Aurora-A |
|
Novel targets of the oncogene Aurora-A |
|
Elucidating the mechanism of human Exonuclease-1 regulation and assessing its role in DNA Replication |
|
Genome-wide functional analysis of ubiquitylation pathways controlling DNA replication |
|
Genome-wide functional analysis of phosphorylation in the DNA response |
|
Myelocytic leukemia as model system to investigate the cell cycle arrest triggered by DNA damage: focus on transcription. |
|
From DNA Damage To The Regulation Of Mitosis: A Study Of The Signaling That Blocks The Cell Division Cycle |
| FGCZ |
Development of advanced bioinformatics tools and strategies for the processing and evaluation of mass spectrometry proteomics data |
|
Development of application-specific surface chemistries for the improvement of microarray substrates |
|
Development of a data integration platform for the management and analysis of heterogeneous functional genomics data. |
| Janscak |
Role of Mismatch Repair Proteins in Homologous Recombination |
|
RecQ DNA helicases and maintenance of genomic stability |
|
Study of the role of mismatch repair proteins in the cellular response to DNA double-strand breaks |
|
Study of the role of the human mismatch repair system in telomere metabolism |
|
Expanding the functional repertoire of the human RECQ5 helicase: functional analysis of the cellular association between RECQ5 and RNA polymerase II |
|
Study of the role of the human RECQ5 helicase in the maintenance of genomic stability |
|
Study of the role of mismatch repair proteins in the cellular response to DNA double-strand breaks |
|
Role of RECQ5 DNA Helicase in Regulation of Homologous Recombination |
|
Exploring the Role of the Human RECQ5 Protein in Maintenance of Genomic Stability |
|
Study of the structure, function and mechanism of action of Bloom syndrome helicase |
| Jiricny |
Proteomic analysis of DNA repair pathways and establishment of a chemical genetic screen for novel anti-cancer agents in the chicken DT40 B lymphocyte line |
|
Genomic instability and cancer |
|
A novel endonuclease involved in resistance to cancer therapy |
|
Interplay between mismatch repair and other pathways of DNA metabolism |
|
DNA damage response and repair mechanisms. |
|
The role of cigarette smoke induced epigenetic DNA modifications in the etiogenesis of lung cancer. |
|
Characterization and quantitative modeling of DNA mismatch repair and its role in the maintenance of genomic stability and cancer avoidance |
|
Study of the mechanisms of mismatch repair in human cells. |
|
Novel approaches towards the therapy of tumours with microsatellite instability |
|
The Role of the Mismatch Repair System in DNA Damage Signalling: Relevance to Drug Resistance in the Therapy of Colon Cancer |
|
Evaluation of genetic and biochemical traits in HNPCC families |
| Lopes |
Towards the structural visualization of genome instability during DNA replication |
| Marra |
Functional characterization of KIAA1199: toward a novel biomarker of colorectal neoplasia. |
|
Functional Characterization of a Novel Biomarker of Colorectal Neoplasia |
|
Evaluation of genomic and gene expression modifications during cellular transformation driven by deficiency of the DNA Mismatch Repair system. |
|
The genetic and genomic alterations of the human PMS2 locus on chromosome 7 that can be associated with predisposition to colon cancer. |
|
Alterations of the human PMS2 gene in the population of central Switzerland |
|
Functional characterization of novel molecular alterations identified in human colon tumors through transcriptomics, metabolomics, and proteomics. |
|
Alterations of the human PMS2 gene in the population of central Switzerland |
|
The genetic and genomic alterations of the human PMS2 locus on chromosome 7 that can be associated with predisposition to colon cancer |
| Schaer |
Thymine DNA-Glycosylase - Antimutator and Tumour Suppressor? |
|
The Role of End-Joining in DNA Double-Strand Break Repair |
| Schärer |
Molecular Mechanisms Underlying Mammalian Nucleotide Excision Repair |
|
DNA Interstrand Crosslink Repair in Mammals |
|
Exploiting DNA Repair for Functional Genomics and Gene Therapy |
| Schweizer |
Microplanar synchrotron X-ray beam irradiation effects in Drosophila melanogaster |
| Schwendener |
Bisphosphonate-liposome mediated depletion of tumor-associated macrophages as new anti-angiogenic tumor therapy approach and as tool for the study of the role of macrophages in the microenvironment of solid tumors |
| Stepanek |
Electron-positron and electron-water atomic interactions |
