Prof. Dr. Max Gassmannmore information

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Current research projects

Project leader Project title
Bogdanova Regulation of red cell life-span, erythropoiesis, survival, senescence and clearance
Gorr Fly as Cancer Model? Genomic Analysis of Drosophila’s Hypoxia Tolerance
Gorr Vogel The role of myoglobin in the tumorigenesis of breast cancer: in vitro and in vivo models for analysis of tumor incidence, proliferation, virulence and response to radiotherapy
Ogunshola Metabolic processes at the blood-brain barrier and their role in vascular dysfunction
Vogel Physiological and pathological angiogenesis in the brain
Premature deafness in clacitonin receptor-like receptor (CLR) transgenic mice

Completed research projects

Project leader Project title
Asarian Intestinal satiation in Roux-en-Y gastric bypass rats: brain mechanisms and sex differences
Translational studies of endocrine and brain controls of eating in rats and pre and postmenopausal women
Beck-Schimmer Impairment of the blood-brain barrier: Evaluation of the effect of pharmacological postconditioning. A study from in vitro to in vivo to the patient
Bogdanova NMDA receptor in the mammalian heart
Acute hypoxic response in the heart
The role of calcium in rare anemia in humans
Development of microfluidics-based technologies for diagnosis of rare anemias, control of treatment efficacy and quality control for stored red blood cells
Memantine in treatment of rare anemia
Assessment of the efficacy of treatment of patients with sickle cell disease with memantine (phase IIa-b trial MemSID) using novel analytical techniques
N-methyl-D-aspartate receptors in red blood cells of mice and men: intracellular Ca2+ as a therapeutic target for the treatment of sickle cell disease
Cardioprotective efficiency of ReII-based CO-releasing complexes
S-glutathionylation as a novel potent mechanism in control of Na,K-ATPase function in the heart: impact of aging and pathology
The role of the glutathione in oxygen-induced regulation of the Na+/K+ pump
Hypoxia-induced responses of cerebellar neurons and myocardium: adaptation vs pathology
Responses of the myocardium and erythrocytes to the changes in oxygenation
Autologous blood-perfused isolated heart: Replacement of heterotopic heart transplantation
Erythropoietin: protecting the heart from cold global ischemia-reperfusion injury
Effects of erythropoietin on mature mammalian erythrocytes
Oxygen-induced regulation of the Na/K ATPase in cardiac myocytes
NMDA receptors in the young and senescent heart: determinant of hypoxia-tolerance
Franchini Ackermann Lutz Reusch Role of toll-like receptors in metabolic diseases
Gassmann The metabolic response to erythropoietin in mice and men: Improving bioenergetic function to help prevent and treat metabolic disease and obesity?
Reduced incidence of cancer at high altitude: analyzing the impact of hypoxia on tumor development
HIF-1 regulates the response to hypoxia
Non-erythroid functions of erythropoietin (Epo)
Impact of varying hematocrit- and erythropoietin-levels to the exercise performance and organ failures
Adaptation to excessive erythrocytosis in transgenic mice overexpressing Epo
HIF, high altitude and exercise
Gassmann Ogunshola Effect of chronic excessive erythrocytosis on vascular function: endothelial dysfunction and inflammation
Gorr Targeting vascularized and hypoxic compartments in solid malignancies: from basic research to dogs with cancer
Embryonic stem cells: tumorigenesis and differentiation linked by intermediary metabolism
Gorr Gassmann HIF-1 interfering transcription factors in cancer cells
Gorr Ogunshola Non-canonical role of 4EBP1 in proliferating and oxygenated primary astrocytes
Gorr Vogel Chorio-allantoic membrane assay for pre-clinical cancer therapy screening: simultaneous targeting of oxygenated and hypoxic tumor cells
CAM assay for targeting tumor vasculature and metabolic symbiosis between oxygenated and hypoxic tumor cells
Grouzman Development of a novel somatostatin analogue G02113 for the treatment of acromegaly and neuroendocrine tumours
Linscheid Reusch Regulation of adiponectin multimer complexes production
Lutz RYGB_cardio Immediate improvement of lipid metabolism, liver and endothelial function after Roux-en-Y gastric bypass (RYGB) surgery in obese humans and rodents
Amylin - from cellular mechanisms to clinical use
Control of food intake by pancreatic and gastrointestinal hormones (Regulation der Nahrungsaufnahme durch Peptidhormone des Pankreas und des Verdauungstraktes)
Hepatic control of food intake
Mechanisms underlying effects of Roux-en-Y gastric bypass surgery on energy expenditure, taste preference and bone metabolism in rats
Interactions of amylin and leptin
Diabetes mellitus in dogs and cats
Effect of bacterial globin on survival of pancreatic beta cells
The mechanism of estrogen’s inhibitory effect on feeding: site and mode of action
Amylin as an adiposity signal and amylin’s role in obesity
The role of amylin the regulation of energy expenditure
Lutz Asarian The mechanism of estrogen’s inhibitory effect on feeding: site and mode of action
Lutz Reusch Ackermann Zini Osto Metabolic studies in cats
Neumann Gaining sage on the Epoetins' saga: assessing long term risks and advancing towards better Epoetin driven treatment modalities
Nitsch Antibody based therapy for type 2 diabetes
Ogunshola Rho GTPases and degenerative disease: The Role of Deoxy-Sphingoid Bases In Diabetes Mellitus And Diabetic Sensory Neuropathy
The contribution of cell-specific HIF-1-mediated pathways to blood-brain barrier function and stability
Cell-specific HIF-1 compromises blood-brain barrier integrity: consequences for stroke outcome
Ischemia and blood brain barrier disruption: in vitro modelling of cellular interactions
Hypoxia and maintenance of cell contacts in neurons
Ischemia and blood brain barrier disruption: in vitro modelling of cellular interactions
Assessment of the beneficial effects of erythropoietin (EPO) in experimental autoimmune encephalomyelitis (EAE)
Molecular mechanisms of the extreme tolerance of astrocytes to hypoxia
Cytoskeleton-mediated hypoxic signalling: Rho GTPases and degenerative disease
Ogunshola Gorr Exploiting hypoxic defense mechanisms to prevent irreversible brain injury and cancer progression: astrocytes could be the key to neuronal survival
Ostergaard Pulmonary hypertension -synergistic effects of sildenafil and erythropoietin
Development of high altitude induced pulmonary edema (HAPE) and the effects of dexamethasone (DXM) treatment
Ostergaard Gassmann Anti „pulmonary-hypertensive“ effects of Erythropoietin
Osto Human-derived antibodies targeting pancreatic islet amyloid for the treatment of type-2 diabetes?
Assessment of gut microbiota in healthy lean, obese and diabetic cats
Gut microbiota, low-grade inflammation and metabolic modifications in myd88 liver specific knock-out mice and after Roux-en-Y gastric bypass (RYGB) surgery in rats
Osto Lutz Reusch Ackermann Subacute endotoxemia: a molecular study to understand the pathogenesis of -cell dysfunction and impaired insulin sensitivity in cats
Riediger Pharmacological approaches against the anorexia-cachexia syndrome
Ghrelin receptor inverse agonists
Interaction between the anorectic hormone amylin and diet derived nutrients
Relevance of nitric oxide (NO) as a neuromodulator involved in disease-related anorexia
Riediger Lutz Electrophysiological characterizations of hormones, neuropeptides and neuromodulators in the arcuate nucleus - a hypothalamic control center for the regulation food intake and body weight
Immunohistological studies identifying feeding-related stimuli modulating neuronal activity in the hypothalamic arcuate nucleus
Immunohistological studies and tracing studies characterizing the phenotype and connectivity of amylin-activated brainstem nuclei
Neurotrophic action of amylin
Soliz Erythropoietin influences oxygen sensing and signalling in hypoxia
Thiersch Analyzing the Role of Erythropoietin Receptor (EpoR) in Cancer Growth and Resistance to Radiotherapy
Vogel Calcitonin gene-related peptide (CGRP) promotes physiological heart hypertrophy
Neuronal Erythropoietin overexpression protects mice against presbyacusis
Arteriogenesis of the uterine arcade and pregnancy outcome
Heterologous VEGF expression in the rodent brain
Negative regulation of the red blood cell mass
Heterologous VEGF expression in the rodent brain
Arteriogenesis of the uterine arcade and pregnancy outcome
Regulation of circulation and organ perfusion in transgenic mice overexpressing the calcitinin receptor-like receptor
Pain sensation in transgenic mice overexpressing the calcitonin receptor-like receptor
Wielinga The role of amylin the regulation of energy expenditure
Amylin as an adiposity signal

Last update 02.03.2017