Prof. Dr. Roland K. O. Sigel - Bioinorganic Chemistrymore information

Fakultäten » Mathematisch-naturwissenschaftliche Fakultät » Anorganisch-chemisches Institut » Prof. Dr. Roland K. O. Sigel

Current research projects

Project leader	Project title
Donghi	Structural NMR investigation of the interaction between metal-based anticancer drugs and RNA
Sigel	Metal Ions and Metal Ion Complexes Guiding Folding and Function of Single RNA Molecules
	Metal Ion-Guided Assembly and Structures of the Catalytic Core of Ribozymes
	RNA quadruplex folding and stabilisation by metal ion complexes on the single molecule level
Sigel König	Splice site formation on the single molecule level
Sigel Rowinska-Zyrek	RIBOZOMICS - lmpact of metal ions on the structure and folding of the human CPEB3
	HumanRib— HumanRib: metal ion binding - stucture - function relations of the human CPEB3 ribozyme

Completed research projects

Project leader	Project title
Johannsen Freisinger Sigel	A: Photoacivated charge transfer in metal-modified nucleic acids B: NMR study on the γ-domain of the plant metallothionein Ec-1 and its cyclic analog
Sigel	Coordination Chemistry within the Core of Large RNAs: Regulating Tertiary Contacts and Function
	Structure, assembly and metal ion binding properties of the catalytic core of a group II intron ribozyme
	Deciphering the role of metal ions in RNA
	Molecular wires based on metal-modified oligonucleotides
	Synthesis and characterization of coenzyme B12 analogs and structural investigations on their interactions with its riboswitch
	The effect of metal ions on splice site formation of group II intron ribozymes
	Metal Ion Sensing by Nucleic Acids in Nature and in the Test Tube
Sigel Barcelo	Light-stable Coenzyme B12 Derivatives and Their Interaction with the btuB Riboswitch from E. coli
Sigel Freisinger	Structures and Thermodynamics of Metallo-Drug Interactions with Nucleobase Derivatives and Nucleic Acids